A Pilot Event-Related Potentials Study on Mechanisms Underlying a tDCS-Enhanced Food-Specific Response Inhibition Task for Patients With Binge Eating Disorder
Behavioural studies demonstrate alterations in cognitive functioning, particularly impaired response inhibition and increased attentional bias towards food in binge eating disorder (BED). This pilot study aimed to investigate the neurophysiological processing of a food-specific inhibition training c...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2021.721672/full |
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| author | Başak İnce Sebastian M. Max Christian Plewnia Elisabeth J. Leehr Stephan Zipfel Stephan Zipfel Katrin Elisabeth Giel Katrin Elisabeth Giel Kathrin Schag Kathrin Schag |
| author_facet | Başak İnce Sebastian M. Max Christian Plewnia Elisabeth J. Leehr Stephan Zipfel Stephan Zipfel Katrin Elisabeth Giel Katrin Elisabeth Giel Kathrin Schag Kathrin Schag |
| author_sort | Başak İnce |
| collection | DOAJ |
| description | Behavioural studies demonstrate alterations in cognitive functioning, particularly impaired response inhibition and increased attentional bias towards food in binge eating disorder (BED). This pilot study aimed to investigate the neurophysiological processing of a food-specific inhibition training combined with anodal transcranial direct current stimulation (tDCS) of the right dorsolateral prefrontal cortex (DLPFC) in 16 patients with BED (mean age = 38.6, mean BMI = 33.7 kg/m2). Patients performed a food-specific antisaccade task at baseline (T0) and in a cross-over design with verum vs. sham stimulation at T1 and T2. We investigated (i) event-related potentials (ERPs; N2, ERN and P3 amplitudes) while executing the task at baseline, (ii) whether baseline ERPs would predict task performance at T1 and T2 and (iii) associations between ERPs, eating disorder pathology and impulsivity at baseline. The mean amplitude of N2 was less pronounced in erroneous saccades (ES) than correct saccades (CS), whereas ERN and P3 mean amplitudes were more pronounced in ES. Moreover, the P3 mean amplitude of ES predicted the percentage of ES at both follow up-measurements irrespective of the applied stimulation (sham vs. verum). N2 in trials with correct saccades were negatively correlated with nonplanning trait impulsivity, while P3 in erroneous antisaccade trials was negatively correlated with food-related impulsivity. Overall, the findings of reduced ERN, enhanced P3 and N2 amplitude might be interpreted as difficulties in response inhibition towards food in individuals with BED. In particular, P3 predicts task outcome at follow-up and might represent a potential marker for inhibitory control processes. |
| first_indexed | 2024-12-22T13:12:37Z |
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| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-22T13:12:37Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-b698554c079643619387ef4267d46c5d2022-12-21T18:24:43ZengFrontiers Media S.A.Frontiers in Psychology1664-10782021-10-011210.3389/fpsyg.2021.721672721672A Pilot Event-Related Potentials Study on Mechanisms Underlying a tDCS-Enhanced Food-Specific Response Inhibition Task for Patients With Binge Eating DisorderBaşak İnce0Sebastian M. Max1Christian Plewnia2Elisabeth J. Leehr3Stephan Zipfel4Stephan Zipfel5Katrin Elisabeth Giel6Katrin Elisabeth Giel7Kathrin Schag8Kathrin Schag9Department of Psychology, Haliç University, Istanbul, TurkeyDepartment of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, GermanyDepartment of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, GermanyInstitute for Translational Psychiatry, University of Münster, Münster, GermanyDepartment of Psychosomatic Medicine & Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), University Hospital Tübingen, Tübingen, GermanyDepartment of Psychosomatic Medicine & Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), University Hospital Tübingen, Tübingen, GermanyDepartment of Psychosomatic Medicine & Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), University Hospital Tübingen, Tübingen, GermanyBehavioural studies demonstrate alterations in cognitive functioning, particularly impaired response inhibition and increased attentional bias towards food in binge eating disorder (BED). This pilot study aimed to investigate the neurophysiological processing of a food-specific inhibition training combined with anodal transcranial direct current stimulation (tDCS) of the right dorsolateral prefrontal cortex (DLPFC) in 16 patients with BED (mean age = 38.6, mean BMI = 33.7 kg/m2). Patients performed a food-specific antisaccade task at baseline (T0) and in a cross-over design with verum vs. sham stimulation at T1 and T2. We investigated (i) event-related potentials (ERPs; N2, ERN and P3 amplitudes) while executing the task at baseline, (ii) whether baseline ERPs would predict task performance at T1 and T2 and (iii) associations between ERPs, eating disorder pathology and impulsivity at baseline. The mean amplitude of N2 was less pronounced in erroneous saccades (ES) than correct saccades (CS), whereas ERN and P3 mean amplitudes were more pronounced in ES. Moreover, the P3 mean amplitude of ES predicted the percentage of ES at both follow up-measurements irrespective of the applied stimulation (sham vs. verum). N2 in trials with correct saccades were negatively correlated with nonplanning trait impulsivity, while P3 in erroneous antisaccade trials was negatively correlated with food-related impulsivity. Overall, the findings of reduced ERN, enhanced P3 and N2 amplitude might be interpreted as difficulties in response inhibition towards food in individuals with BED. In particular, P3 predicts task outcome at follow-up and might represent a potential marker for inhibitory control processes.https://www.frontiersin.org/articles/10.3389/fpsyg.2021.721672/fullbinge eating disorderresponse inhibitionimpulsivityantisaccadecognitive controlevent-related potentials |
| spellingShingle | Başak İnce Sebastian M. Max Christian Plewnia Elisabeth J. Leehr Stephan Zipfel Stephan Zipfel Katrin Elisabeth Giel Katrin Elisabeth Giel Kathrin Schag Kathrin Schag A Pilot Event-Related Potentials Study on Mechanisms Underlying a tDCS-Enhanced Food-Specific Response Inhibition Task for Patients With Binge Eating Disorder Frontiers in Psychology binge eating disorder response inhibition impulsivity antisaccade cognitive control event-related potentials |
| title | A Pilot Event-Related Potentials Study on Mechanisms Underlying a tDCS-Enhanced Food-Specific Response Inhibition Task for Patients With Binge Eating Disorder |
| title_full | A Pilot Event-Related Potentials Study on Mechanisms Underlying a tDCS-Enhanced Food-Specific Response Inhibition Task for Patients With Binge Eating Disorder |
| title_fullStr | A Pilot Event-Related Potentials Study on Mechanisms Underlying a tDCS-Enhanced Food-Specific Response Inhibition Task for Patients With Binge Eating Disorder |
| title_full_unstemmed | A Pilot Event-Related Potentials Study on Mechanisms Underlying a tDCS-Enhanced Food-Specific Response Inhibition Task for Patients With Binge Eating Disorder |
| title_short | A Pilot Event-Related Potentials Study on Mechanisms Underlying a tDCS-Enhanced Food-Specific Response Inhibition Task for Patients With Binge Eating Disorder |
| title_sort | pilot event related potentials study on mechanisms underlying a tdcs enhanced food specific response inhibition task for patients with binge eating disorder |
| topic | binge eating disorder response inhibition impulsivity antisaccade cognitive control event-related potentials |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2021.721672/full |
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