A review on biomarkers in clinical osteoporosis - Significance of hydroxyproline
Osteoporosis is a chronic disorder in both men and women, where it decreases the bone quality and quantity, which may lead to a fall in bone mass density. It mostly occurs because of reduced peak bone mass or excessive formation or resorption during bone remodeling. Various degradation products of b...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Biomedical and Biotechnology Research Journal |
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| Online Access: | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2021;volume=5;issue=3;spage=245;epage=251;aulast=Adugani |
| _version_ | 1818588503584276480 |
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| author | Soumya Adugani Gurupadayya Bannimath Purushothama Sastry |
| author_facet | Soumya Adugani Gurupadayya Bannimath Purushothama Sastry |
| author_sort | Soumya Adugani |
| collection | DOAJ |
| description | Osteoporosis is a chronic disorder in both men and women, where it decreases the bone quality and quantity, which may lead to a fall in bone mass density. It mostly occurs because of reduced peak bone mass or excessive formation or resorption during bone remodeling. Various degradation products of bone collagen are pyridinoline (Pyr), deoxypyridinoline, N-terminal telopeptides, and hydroxyproline (Hyp), which are excreted in the urine. Among that, Hyp is a crucial biomarker used to correlate osteoporosis condition. An overview of all the biomarkers and the signed note of Hyp with different analytical methods are provided in the current piece of work. To quantify amounts in biological samples, various methods have been developed for Hyp analysis, such as the colorimetric technique, gas chromatography, gas chromatography-mass spectrometry, and widely used high-performance liquid chromatography tests to detect the concentration of Hyp in different matrices. This review states the importance of biomarkers and Hyp's significance for detecting osteoporosis, clinical manifestation, and different analytical methods for Hyp. The study indicates that hydroxyproline is a unique biomarker used to detect osteoporosis. It is also showing the clinical manifestation of osteoporosis and discussed different analytical methods for hydroxyproline. |
| first_indexed | 2024-12-16T09:25:47Z |
| format | Article |
| id | doaj.art-b6991efd80f046929557f0b97772a733 |
| institution | Directory Open Access Journal |
| issn | 2588-9834 |
| language | English |
| last_indexed | 2024-12-16T09:25:47Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Biomedical and Biotechnology Research Journal |
| spelling | doaj.art-b6991efd80f046929557f0b97772a7332022-12-21T22:36:39ZengWolters Kluwer Medknow PublicationsBiomedical and Biotechnology Research Journal2588-98342021-01-015324525110.4103/bbrj.bbrj_91_21A review on biomarkers in clinical osteoporosis - Significance of hydroxyprolineSoumya AduganiGurupadayya BannimathPurushothama SastryOsteoporosis is a chronic disorder in both men and women, where it decreases the bone quality and quantity, which may lead to a fall in bone mass density. It mostly occurs because of reduced peak bone mass or excessive formation or resorption during bone remodeling. Various degradation products of bone collagen are pyridinoline (Pyr), deoxypyridinoline, N-terminal telopeptides, and hydroxyproline (Hyp), which are excreted in the urine. Among that, Hyp is a crucial biomarker used to correlate osteoporosis condition. An overview of all the biomarkers and the signed note of Hyp with different analytical methods are provided in the current piece of work. To quantify amounts in biological samples, various methods have been developed for Hyp analysis, such as the colorimetric technique, gas chromatography, gas chromatography-mass spectrometry, and widely used high-performance liquid chromatography tests to detect the concentration of Hyp in different matrices. This review states the importance of biomarkers and Hyp's significance for detecting osteoporosis, clinical manifestation, and different analytical methods for Hyp. The study indicates that hydroxyproline is a unique biomarker used to detect osteoporosis. It is also showing the clinical manifestation of osteoporosis and discussed different analytical methods for hydroxyproline.http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2021;volume=5;issue=3;spage=245;epage=251;aulast=Aduganibone mass densityhigh-performance liquid chromatographyhydroxyprolineosteoporosis |
| spellingShingle | Soumya Adugani Gurupadayya Bannimath Purushothama Sastry A review on biomarkers in clinical osteoporosis - Significance of hydroxyproline Biomedical and Biotechnology Research Journal bone mass density high-performance liquid chromatography hydroxyproline osteoporosis |
| title | A review on biomarkers in clinical osteoporosis - Significance of hydroxyproline |
| title_full | A review on biomarkers in clinical osteoporosis - Significance of hydroxyproline |
| title_fullStr | A review on biomarkers in clinical osteoporosis - Significance of hydroxyproline |
| title_full_unstemmed | A review on biomarkers in clinical osteoporosis - Significance of hydroxyproline |
| title_short | A review on biomarkers in clinical osteoporosis - Significance of hydroxyproline |
| title_sort | review on biomarkers in clinical osteoporosis significance of hydroxyproline |
| topic | bone mass density high-performance liquid chromatography hydroxyproline osteoporosis |
| url | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2021;volume=5;issue=3;spage=245;epage=251;aulast=Adugani |
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