COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance?
The COVID-19 vaccines currently in use have undoubtedly played the most significant role in combating the SARS-CoV-2 virus and reducing disease severity and the risk of death among those affected, especially among those with pre-existing conditions, such as diabetes. The management of blood glucose...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/3/454 |
| _version_ | 1797441171255984128 |
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| author | Samson Mathews Samuel Elizabeth Varghese Chris R. Triggle Dietrich Büsselberg |
| author_facet | Samson Mathews Samuel Elizabeth Varghese Chris R. Triggle Dietrich Büsselberg |
| author_sort | Samson Mathews Samuel |
| collection | DOAJ |
| description | The COVID-19 vaccines currently in use have undoubtedly played the most significant role in combating the SARS-CoV-2 virus and reducing disease severity and the risk of death among those affected, especially among those with pre-existing conditions, such as diabetes. The management of blood glucose levels has become critical in the context of the COVID-19 pandemic, where data show two- to threefold higher intensive care hospital admissions and more than twice the mortality rate among diabetic COVID-19 patients when compared with their nondiabetic counterparts. Furthermore, new-onset diabetes and severe hyperglycemia-related complications, such as hyperosmolar hyperglycemic syndrome (HHS) and diabetic ketoacidosis (DKA), were reported in COVID-19 patients. However, irrespective of the kind of vaccine and dosage number, possible vaccination-induced hyperglycemia and associated complications were reported among vaccinated individuals. The current article summarizes the available case reports on COVID-19 vaccination-induced hyperglycemia, the possible molecular mechanism responsible for this phenomenon, and the outstanding questions that need to be addressed and discusses the need to identify at-risk individuals and promote postvaccination monitoring/surveillance among at-risk individuals. |
| first_indexed | 2024-03-09T12:19:09Z |
| format | Article |
| id | doaj.art-b699463d71c945d3a1eb916ab205f8d5 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:19:09Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-b699463d71c945d3a1eb916ab205f8d52023-11-30T22:43:10ZengMDPI AGVaccines2076-393X2022-03-0110345410.3390/vaccines10030454COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance?Samson Mathews Samuel0Elizabeth Varghese1Chris R. Triggle2Dietrich Büsselberg3Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha P.O. Box 24144, QatarDepartment of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha P.O. Box 24144, QatarDepartment of Pharmacology, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha P.O. Box 24144, QatarDepartment of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha P.O. Box 24144, QatarThe COVID-19 vaccines currently in use have undoubtedly played the most significant role in combating the SARS-CoV-2 virus and reducing disease severity and the risk of death among those affected, especially among those with pre-existing conditions, such as diabetes. The management of blood glucose levels has become critical in the context of the COVID-19 pandemic, where data show two- to threefold higher intensive care hospital admissions and more than twice the mortality rate among diabetic COVID-19 patients when compared with their nondiabetic counterparts. Furthermore, new-onset diabetes and severe hyperglycemia-related complications, such as hyperosmolar hyperglycemic syndrome (HHS) and diabetic ketoacidosis (DKA), were reported in COVID-19 patients. However, irrespective of the kind of vaccine and dosage number, possible vaccination-induced hyperglycemia and associated complications were reported among vaccinated individuals. The current article summarizes the available case reports on COVID-19 vaccination-induced hyperglycemia, the possible molecular mechanism responsible for this phenomenon, and the outstanding questions that need to be addressed and discusses the need to identify at-risk individuals and promote postvaccination monitoring/surveillance among at-risk individuals.https://www.mdpi.com/2076-393X/10/3/454COVID-19diabetesdiabetic ketoacidosishyperglycemiahyperosmolar hyperglycemic syndromeSARS-CoV-2 |
| spellingShingle | Samson Mathews Samuel Elizabeth Varghese Chris R. Triggle Dietrich Büsselberg COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance? Vaccines COVID-19 diabetes diabetic ketoacidosis hyperglycemia hyperosmolar hyperglycemic syndrome SARS-CoV-2 |
| title | COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance? |
| title_full | COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance? |
| title_fullStr | COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance? |
| title_full_unstemmed | COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance? |
| title_short | COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance? |
| title_sort | covid 19 vaccines and hyperglycemia is there a need for postvaccination surveillance |
| topic | COVID-19 diabetes diabetic ketoacidosis hyperglycemia hyperosmolar hyperglycemic syndrome SARS-CoV-2 |
| url | https://www.mdpi.com/2076-393X/10/3/454 |
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