The role of receptor‐type protein tyrosine phosphatases in cancer
Abstract Receptor‐type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes the expression and role of RPTPs in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | Precision Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/prm2.12090 |
| _version_ | 1797871025026760704 |
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| author | Zhengyuan Lv Tianming Wang Xin Cao Mengting Sun Yuan Qu |
| author_facet | Zhengyuan Lv Tianming Wang Xin Cao Mengting Sun Yuan Qu |
| author_sort | Zhengyuan Lv |
| collection | DOAJ |
| description | Abstract Receptor‐type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes the expression and role of RPTPs in cancer and illustrates the signaling pathway mechanisms of effecting oncogenesis, tumor progression, prognosis, and angiogenesis, so as to provide more effective targets for gene therapy of related cancers. |
| first_indexed | 2024-04-10T00:37:46Z |
| format | Article |
| id | doaj.art-b69b003caa624b02b150e4137f6af56d |
| institution | Directory Open Access Journal |
| issn | 2642-2514 |
| language | English |
| last_indexed | 2024-04-10T00:37:46Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Medical Sciences |
| spelling | doaj.art-b69b003caa624b02b150e4137f6af56d2023-03-14T13:37:47ZengWileyPrecision Medical Sciences2642-25142023-03-01121485710.1002/prm2.12090The role of receptor‐type protein tyrosine phosphatases in cancerZhengyuan Lv0Tianming Wang1Xin Cao2Mengting Sun3Yuan Qu4Department of Medical Genetics, School of Basic Medical Science Nanjing Medical University Nanjing ChinaDepartment of Medical Genetics, School of Basic Medical Science Nanjing Medical University Nanjing ChinaDepartment of Medical Genetics, School of Basic Medical Science Nanjing Medical University Nanjing ChinaBiobank of Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaJiangsu Cancer Hospital, Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaAbstract Receptor‐type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes the expression and role of RPTPs in cancer and illustrates the signaling pathway mechanisms of effecting oncogenesis, tumor progression, prognosis, and angiogenesis, so as to provide more effective targets for gene therapy of related cancers.https://doi.org/10.1002/prm2.12090cancerRPTPsreversible phosphorylation |
| spellingShingle | Zhengyuan Lv Tianming Wang Xin Cao Mengting Sun Yuan Qu The role of receptor‐type protein tyrosine phosphatases in cancer Precision Medical Sciences cancer RPTPs reversible phosphorylation |
| title | The role of receptor‐type protein tyrosine phosphatases in cancer |
| title_full | The role of receptor‐type protein tyrosine phosphatases in cancer |
| title_fullStr | The role of receptor‐type protein tyrosine phosphatases in cancer |
| title_full_unstemmed | The role of receptor‐type protein tyrosine phosphatases in cancer |
| title_short | The role of receptor‐type protein tyrosine phosphatases in cancer |
| title_sort | role of receptor type protein tyrosine phosphatases in cancer |
| topic | cancer RPTPs reversible phosphorylation |
| url | https://doi.org/10.1002/prm2.12090 |
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