Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice
Abstract Runt-related transcription factor 2 (Runx2)-deficient mice can be used to model congenital tooth agenesis in humans. Conversely, uterine sensitization-associated gene-1 (Usag-1)-deficient mice exhibit supernumerary tooth formation. Arrested tooth formation can be restored by crossing both k...
Main Authors: | Sayaka Mishima, Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Jun-Ichiro Jo, Ryuji Uozumi, Yukiko Nambu, Boyen Huang, Hidemitsu Harada, Toshihisa Komori, Manabu Sugai, Yasuhiko Tabata, Kazuhisa Bessho |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2021-07-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-93256-y |
Similar Items
-
Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development.
by: Yumiko Togo, et al.
Published: (2016-01-01) -
Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations.
by: Honoka Kiso, et al.
Published: (2014-01-01) -
Advances in tooth agenesis and tooth regeneration
by: V. Ravi, et al.
Published: (2023-03-01) -
Increased risk of temporomandibular joint closed lock: a case-control study of ANKH polymorphisms.
by: Boyen Huang, et al.
Published: (2011-01-01) -
Whole Aspect of Runx2 Functions in Skeletal Development
by: Toshihisa Komori
Published: (2022-05-01)