Lestaurtinib inhibits Citron kinase activity and medulloblastoma growth through induction of DNA damage, apoptosis and cytokinesis failure

Lestaurtinib inhibits Citron kinase activity and medulloblastoma growth through induction of DNA damage, apoptosis and cytokinesis failure

IntroductionMedulloblastoma (MB), the most common malignant pediatric brain tumor, is currently treated with surgery followed by radiation and chemotherapy, which is accompanied by severe side effects, raising the need for innovative therapies. Disruption of the microcephaly-related gene Citron kina...

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Bibliographic Details
Main Authors: Gianmarco Pallavicini, Giorgia Iegiani, Roberta Parolisi, Alessia Ferraro, Francesca Garello, Valeria Bitonto, Enzo Terreno, Marta Gai, Ferdinando Di Cunto
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Oncology
Subjects:
Lestaurtinib
CitK
drug repurposing
medulloblastoma
preclinical studies
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1202585/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1202585/full

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