Lestaurtinib inhibits Citron kinase activity and medulloblastoma growth through induction of DNA damage, apoptosis and cytokinesis failure
IntroductionMedulloblastoma (MB), the most common malignant pediatric brain tumor, is currently treated with surgery followed by radiation and chemotherapy, which is accompanied by severe side effects, raising the need for innovative therapies. Disruption of the microcephaly-related gene Citron kina...
Main Authors: | Gianmarco Pallavicini, Giorgia Iegiani, Roberta Parolisi, Alessia Ferraro, Francesca Garello, Valeria Bitonto, Enzo Terreno, Marta Gai, Ferdinando Di Cunto |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-06-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1202585/full |
Similar Items
-
The impact of TP53 activation and apoptosis in primary hereditary microcephaly
by: Giorgia Iegiani, et al.
Published: (2023-06-01) -
CENPE Inhibition Leads to Mitotic Catastrophe and DNA Damage in Medulloblastoma Cells
by: Giorgia Iegiani, et al.
Published: (2021-03-01) -
CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents
by: Gianmarco Pallavicini, et al.
Published: (2020-02-01) -
Lestaurtinib induces DNA damage that is related to estrogen receptor activation
by: Masato Ooka, et al.
Published: (2023-01-01) -
Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors
by: Gianmarco Pallavicini, et al.
Published: (2019-04-01)