Genome-scale CRISPR screening for modifiers of cellular LDL uptake.

Genome-scale CRISPR screening for modifiers of cellular LDL uptake.

Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis involves the receptor-mediated endocytosis of low-density lipoproteins into hepatocytes, mediated by the LDL receptor. We applied genome-scale...

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Bibliographic Details
Main Authors: Brian T Emmer, Emily J Sherman, Paul J Lascuna, Sarah E Graham, Cristen J Willer, David Ginsburg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009285

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