TFEB Biology and Agonists at a Glance
Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/2/333 |
| _version_ | 1827603144472788992 |
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| author | Mingyue Chen Yashuang Dai Siyu Liu Yuxin Fan Zongxian Ding Dan Li |
| author_facet | Mingyue Chen Yashuang Dai Siyu Liu Yuxin Fan Zongxian Ding Dan Li |
| author_sort | Mingyue Chen |
| collection | DOAJ |
| description | Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysosome, can enhance autophagic and lysosomal biogenesis and function. TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of disease models, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity. Therefore, TFEB agonists are a promising strategy to ameliorate diseases implicated with autophagy dysfunction. Recently, several TFEB agonists have been identified and preclinical or clinical trials are applied. In this review, we present an overview of the latest research on TFEB biology and TFEB agonists. |
| first_indexed | 2024-03-09T05:32:35Z |
| format | Article |
| id | doaj.art-b69df197ae464ddebbffccf258ce44e1 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T05:32:35Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b69df197ae464ddebbffccf258ce44e12023-12-03T12:31:22ZengMDPI AGCells2073-44092021-02-0110233310.3390/cells10020333TFEB Biology and Agonists at a GlanceMingyue Chen0Yashuang Dai1Siyu Liu2Yuxin Fan3Zongxian Ding4Dan Li5Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310000, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310000, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310000, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310000, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310000, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310000, ChinaAutophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysosome, can enhance autophagic and lysosomal biogenesis and function. TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of disease models, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity. Therefore, TFEB agonists are a promising strategy to ameliorate diseases implicated with autophagy dysfunction. Recently, several TFEB agonists have been identified and preclinical or clinical trials are applied. In this review, we present an overview of the latest research on TFEB biology and TFEB agonists.https://www.mdpi.com/2073-4409/10/2/333TFEB agonistsautophagylysosomerapamycinresveratrol |
| spellingShingle | Mingyue Chen Yashuang Dai Siyu Liu Yuxin Fan Zongxian Ding Dan Li TFEB Biology and Agonists at a Glance Cells TFEB agonists autophagy lysosome rapamycin resveratrol |
| title | TFEB Biology and Agonists at a Glance |
| title_full | TFEB Biology and Agonists at a Glance |
| title_fullStr | TFEB Biology and Agonists at a Glance |
| title_full_unstemmed | TFEB Biology and Agonists at a Glance |
| title_short | TFEB Biology and Agonists at a Glance |
| title_sort | tfeb biology and agonists at a glance |
| topic | TFEB agonists autophagy lysosome rapamycin resveratrol |
| url | https://www.mdpi.com/2073-4409/10/2/333 |
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