Decoding the anti-Leishmania braziliensis activity of 1,10-phenanthroline-5,6-dione and its silver- and copper-based complexes: In vitro and in vivo approaches

Decoding the anti-Leishmania braziliensis activity of 1,10-phenanthroline-5,6-dione and its silver- and copper-based complexes: In vitro and in vivo approaches

Leishmaniasis is a neglected tropical disease, whose chemotherapy still presents a series of severe side effects for the patient. Recently, our group published the leishmanicidal action of 1,10-phenanthroline (1), 1,10-phenanthroline-5,6-dione (phendione, 2) and its silver(I) [Ag(phendione)2]ClO4 (3...

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Bibliographic Details
Main Authors: André L.S. Santos, Ana Karina C. Lima, Simone S.C. Oliveira, Rosiane F. dos Santos, Michael Devereux, Malachy McCann, Marta H. Branquinha, Patrícia M.L. Dutra
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Leishmania
Chemotherapy
Coordination complexes
1,10-Phenanthroline-5,6-dione
Virulence
Infection
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417422000656

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http://www.sciencedirect.com/science/article/pii/S2772417422000656

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