Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance
Increasing evidence indicates that endoplasmic reticulum stress (ER stress) is involved in the development of metabolic syndrome. However, pharmacological treatments targeting ER stress are not well understood. In the present study, we found that fluvoxamine, a selective serotonin reuptake inhibit...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00012/full |
| _version_ | 1819054269785964544 |
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| author | Toru eHosoi Tsuyoshi eMiyahara Takaaki eKayano Shota eYokoyama Koichiro eOzawa |
| author_facet | Toru eHosoi Tsuyoshi eMiyahara Takaaki eKayano Shota eYokoyama Koichiro eOzawa |
| author_sort | Toru eHosoi |
| collection | DOAJ |
| description | Increasing evidence indicates that endoplasmic reticulum stress (ER stress) is involved in the development of metabolic syndrome. However, pharmacological treatments targeting ER stress are not well understood. In the present study, we found that fluvoxamine, a selective serotonin reuptake inhibitor used for depression, can attenuate ER stress-induced leptin resistance, i.e. insensitivity to the anti-obesity hormone leptin. Treatment with tunicamycin, an ER stress-inducing reagent, caused cell death which was significantly inhibited by fluvoxamine. Leptin activates JAK2-STAT3 signaling. ER stress caused an impairment of leptin-induced STAT3 phosphorylation which was reversed by fluvoxamine. Fluvoxamine would be a novel leptin-sensitizing drug, which targets ER stress. |
| first_indexed | 2024-12-21T12:48:57Z |
| format | Article |
| id | doaj.art-b6a0711d66844313806015fb684f9f47 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-21T12:48:57Z |
| publishDate | 2012-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b6a0711d66844313806015fb684f9f472022-12-21T19:03:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922012-01-01310.3389/fendo.2012.0001211239Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistanceToru eHosoi0Tsuyoshi eMiyahara1Takaaki eKayano2Shota eYokoyama3Koichiro eOzawa4Hiroshima UniversityHiroshima UniversityHiroshima UniversityHiroshima UniversityHiroshima UniversityIncreasing evidence indicates that endoplasmic reticulum stress (ER stress) is involved in the development of metabolic syndrome. However, pharmacological treatments targeting ER stress are not well understood. In the present study, we found that fluvoxamine, a selective serotonin reuptake inhibitor used for depression, can attenuate ER stress-induced leptin resistance, i.e. insensitivity to the anti-obesity hormone leptin. Treatment with tunicamycin, an ER stress-inducing reagent, caused cell death which was significantly inhibited by fluvoxamine. Leptin activates JAK2-STAT3 signaling. ER stress caused an impairment of leptin-induced STAT3 phosphorylation which was reversed by fluvoxamine. Fluvoxamine would be a novel leptin-sensitizing drug, which targets ER stress.http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00012/fullDepressionEndoplasmic Reticulum StressFluvoxamineLeptinObesitystat3 |
| spellingShingle | Toru eHosoi Tsuyoshi eMiyahara Takaaki eKayano Shota eYokoyama Koichiro eOzawa Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance Frontiers in Endocrinology Depression Endoplasmic Reticulum Stress Fluvoxamine Leptin Obesity stat3 |
| title | Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance |
| title_full | Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance |
| title_fullStr | Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance |
| title_full_unstemmed | Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance |
| title_short | Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance |
| title_sort | fluvoxamine attenuated endoplasmic reticulum stress induced leptin resistance |
| topic | Depression Endoplasmic Reticulum Stress Fluvoxamine Leptin Obesity stat3 |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00012/full |
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