<italic>In Vivo</italic> Fascicle Bifurcation Imaging of Rat Sciatic Nerve Using Swept-Source Optical Coherence Tomography
The sciatic nerve is the longest and widest single nerve in the human body and is responsible for the signal transduction of the entire hind limb region. Its wide nerve dynamic range and size makes it sensitive to injury. The branching and location of the sciatic nerve are important, and unlike hist...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IEEE
2018-01-01
|
| Series: | IEEE Access |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/8287801/ |
| _version_ | 1818619244926992384 |
|---|---|
| author | Daeyoung Choi Jaeyul Lee Mansik Jeon Jeehyun Kim |
| author_facet | Daeyoung Choi Jaeyul Lee Mansik Jeon Jeehyun Kim |
| author_sort | Daeyoung Choi |
| collection | DOAJ |
| description | The sciatic nerve is the longest and widest single nerve in the human body and is responsible for the signal transduction of the entire hind limb region. Its wide nerve dynamic range and size makes it sensitive to injury. The branching and location of the sciatic nerve are important, and unlike histology, optical coherence tomography (OCT) can provide rapid non-destructive cross-sectional images. The sciatic nerves of ten rats were analyzed using swept-source (SS)-OCT. The sufficient depth penetration of the SS-OCT system allowed clear identification of the internal bifurcation point of the external branching and the internal route for the three terminal nerves in cross-sectional images. Internal bifurcation is observed through interfascicular epineurium resulting from epineurium division. Two bifurcations occur at the bottom of the sciatic nerve. The first and second bifurcations occur approximately 7 and 5 mm, respectively, above the external branching. SS-OCT enabled visualization of surgical needle positioning during direct injections into the sciatic nerve, which is beneficial for drug injection or microelectrode placement for electrical signal processing as a nerve detection guide. Therefore, analysis of the internal structure obtained in real time and needle position information inside the nerve are expected to act as a guide for neurosurgery. |
| first_indexed | 2024-12-16T17:34:25Z |
| format | Article |
| id | doaj.art-b6a12163dd134a86b4690f8e872d60a7 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-12-16T17:34:25Z |
| publishDate | 2018-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-b6a12163dd134a86b4690f8e872d60a72022-12-21T22:22:51ZengIEEEIEEE Access2169-35362018-01-0167713771810.1109/ACCESS.2018.27966258287801<italic>In Vivo</italic> Fascicle Bifurcation Imaging of Rat Sciatic Nerve Using Swept-Source Optical Coherence TomographyDaeyoung Choi0Jaeyul Lee1Mansik Jeon2https://orcid.org/0000-0002-0630-9039Jeehyun Kim3School of Electronics Engineering, College of IT Engineering, Kyungpook National University, Daegu, South KoreaSchool of Electronics Engineering, College of IT Engineering, Kyungpook National University, Daegu, South KoreaSchool of Electronics Engineering, College of IT Engineering, Kyungpook National University, Daegu, South KoreaSchool of Electronics Engineering, College of IT Engineering, Kyungpook National University, Daegu, South KoreaThe sciatic nerve is the longest and widest single nerve in the human body and is responsible for the signal transduction of the entire hind limb region. Its wide nerve dynamic range and size makes it sensitive to injury. The branching and location of the sciatic nerve are important, and unlike histology, optical coherence tomography (OCT) can provide rapid non-destructive cross-sectional images. The sciatic nerves of ten rats were analyzed using swept-source (SS)-OCT. The sufficient depth penetration of the SS-OCT system allowed clear identification of the internal bifurcation point of the external branching and the internal route for the three terminal nerves in cross-sectional images. Internal bifurcation is observed through interfascicular epineurium resulting from epineurium division. Two bifurcations occur at the bottom of the sciatic nerve. The first and second bifurcations occur approximately 7 and 5 mm, respectively, above the external branching. SS-OCT enabled visualization of surgical needle positioning during direct injections into the sciatic nerve, which is beneficial for drug injection or microelectrode placement for electrical signal processing as a nerve detection guide. Therefore, analysis of the internal structure obtained in real time and needle position information inside the nerve are expected to act as a guide for neurosurgery.https://ieeexplore.ieee.org/document/8287801/Nervessciatic nerveintraneural injectionbifurcationswept-source optical coherence tomography |
| spellingShingle | Daeyoung Choi Jaeyul Lee Mansik Jeon Jeehyun Kim <italic>In Vivo</italic> Fascicle Bifurcation Imaging of Rat Sciatic Nerve Using Swept-Source Optical Coherence Tomography IEEE Access Nerves sciatic nerve intraneural injection bifurcation swept-source optical coherence tomography |
| title | <italic>In Vivo</italic> Fascicle Bifurcation Imaging of Rat Sciatic Nerve Using Swept-Source Optical Coherence Tomography |
| title_full | <italic>In Vivo</italic> Fascicle Bifurcation Imaging of Rat Sciatic Nerve Using Swept-Source Optical Coherence Tomography |
| title_fullStr | <italic>In Vivo</italic> Fascicle Bifurcation Imaging of Rat Sciatic Nerve Using Swept-Source Optical Coherence Tomography |
| title_full_unstemmed | <italic>In Vivo</italic> Fascicle Bifurcation Imaging of Rat Sciatic Nerve Using Swept-Source Optical Coherence Tomography |
| title_short | <italic>In Vivo</italic> Fascicle Bifurcation Imaging of Rat Sciatic Nerve Using Swept-Source Optical Coherence Tomography |
| title_sort | italic in vivo italic fascicle bifurcation imaging of rat sciatic nerve using swept source optical coherence tomography |
| topic | Nerves sciatic nerve intraneural injection bifurcation swept-source optical coherence tomography |
| url | https://ieeexplore.ieee.org/document/8287801/ |
| work_keys_str_mv | AT daeyoungchoi italicinvivoitalicfasciclebifurcationimagingofratsciaticnerveusingsweptsourceopticalcoherencetomography AT jaeyullee italicinvivoitalicfasciclebifurcationimagingofratsciaticnerveusingsweptsourceopticalcoherencetomography AT mansikjeon italicinvivoitalicfasciclebifurcationimagingofratsciaticnerveusingsweptsourceopticalcoherencetomography AT jeehyunkim italicinvivoitalicfasciclebifurcationimagingofratsciaticnerveusingsweptsourceopticalcoherencetomography |