Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation Failure
Yang Liu,1– 6,* Xiangxin Lan,1– 6,* Juanjuan Lu,1– 6,* Qian Zhang,1– 6 Tingting Zhou,1– 6 Tianxiang Ni,1– 6 Junhao Yan1– 6 1Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Key Laboratory of Reproductive Endocrinolog...
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Dove Medical Press
2024-02-01
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| Series: | The Application of Clinical Genetics |
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| Online Access: | https://www.dovepress.com/preimplantation-genetic-testing-for-aneuploidy-could-not-improve-cumul-peer-reviewed-fulltext-article-TACG |
| _version_ | 1827366048143245312 |
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| author | Liu Y Lan X Lu J Zhang Q Zhou T Ni T Yan J |
| author_facet | Liu Y Lan X Lu J Zhang Q Zhou T Ni T Yan J |
| author_sort | Liu Y |
| collection | DOAJ |
| description | Yang Liu,1– 6,* Xiangxin Lan,1– 6,* Juanjuan Lu,1– 6,* Qian Zhang,1– 6 Tingting Zhou,1– 6 Tianxiang Ni,1– 6 Junhao Yan1– 6 1Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 3Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, People’s Republic of China; 4Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, People’s Republic of China; 5Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, People’s Republic of China; 6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tianxiang Ni; Junhao Yan, Center for Reproductive Medicine, Shandong University, Jinan, People’s Republic of China, Tel +0531-85651172, Email tianxiangni907@163.com; yyy306@126.comObjective: We evaluate whether next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A) improves the cumulative pregnancy outcomes of patients with unexplained recurrent implantation failure (uRIF) as compared to conventional in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI).Patients and Methods: This was a retrospective cohort study (2015– 2022). A total of 705 couples diagnosed with uRIF were included in the study. 229 women transferred blastocysts based on morphological grading (IVF/ICSI) and 476 couples opted for PGT-A to screen blastocysts by NGS. Women were further stratified according to age at retrieval (< 38 years and ≥ 38 years). The primary outcome was the cumulative live-birth rate after all the embryos were transferred in a single oocyte retrieval or until achieving a live birth. Confounders were adjusted using binary logistic regression models.Results: Cumulative live-birth rate was similar between the IVF/ICSI group and the PGT-A group after stratified by age: IVF/ICSI vs PGT-A in the < 38 years subgroup (49.7% vs 57.7%, adjusted OR (95% CI) = 1.25 (0.84– 1.84), P = 0.270) and in the ≥ 38 years subgroup (14.0% vs 19.5%, adjusted OR (95% CI) = 1.09 (0.41– 2.92), P = 0.866), respectively. Nonetheless, the PGT group had a lower first-time biochemical pregnancy loss rate (17.0% vs 8.7%, P = 0.034) and a higher cumulative good birth outcome rate (35.2% vs 46.4%, P = 0.014) than the IVF/ICSI group in the < 38 years subgroup. Other pregnancy outcomes after the initial embryo transfer and multiple transfers following a single oocyte retrieval were all similar between groups.Conclusion: Our results showed no evidence of favorable effects of PGT-A treatment on improving the cumulative live birth rate in uRIF couples regardless of maternal age. Use of PGT-A in the < 38 years uRIF patients would help to decrease the first-time biochemical pregnancy loss and increase the cumulative good birth outcome.Keywords: preimplantation genetic testing for aneuploidy, unexplained recurrent implantation failure, cumulative live-birth rate, cumulative good birth outcome |
| first_indexed | 2024-03-08T08:42:38Z |
| format | Article |
| id | doaj.art-b6a1a6345f7640b8be1f9c2b55acd2d2 |
| institution | Directory Open Access Journal |
| issn | 1178-704X |
| language | English |
| last_indexed | 2024-03-08T08:42:38Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | The Application of Clinical Genetics |
| spelling | doaj.art-b6a1a6345f7640b8be1f9c2b55acd2d22024-02-01T17:59:28ZengDove Medical PressThe Application of Clinical Genetics1178-704X2024-02-01Volume 1711390128Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation FailureLiu YLan XLu JZhang QZhou TNi TYan JYang Liu,1– 6,* Xiangxin Lan,1– 6,* Juanjuan Lu,1– 6,* Qian Zhang,1– 6 Tingting Zhou,1– 6 Tianxiang Ni,1– 6 Junhao Yan1– 6 1Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 3Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, People’s Republic of China; 4Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, People’s Republic of China; 5Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, People’s Republic of China; 6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tianxiang Ni; Junhao Yan, Center for Reproductive Medicine, Shandong University, Jinan, People’s Republic of China, Tel +0531-85651172, Email tianxiangni907@163.com; yyy306@126.comObjective: We evaluate whether next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A) improves the cumulative pregnancy outcomes of patients with unexplained recurrent implantation failure (uRIF) as compared to conventional in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI).Patients and Methods: This was a retrospective cohort study (2015– 2022). A total of 705 couples diagnosed with uRIF were included in the study. 229 women transferred blastocysts based on morphological grading (IVF/ICSI) and 476 couples opted for PGT-A to screen blastocysts by NGS. Women were further stratified according to age at retrieval (< 38 years and ≥ 38 years). The primary outcome was the cumulative live-birth rate after all the embryos were transferred in a single oocyte retrieval or until achieving a live birth. Confounders were adjusted using binary logistic regression models.Results: Cumulative live-birth rate was similar between the IVF/ICSI group and the PGT-A group after stratified by age: IVF/ICSI vs PGT-A in the < 38 years subgroup (49.7% vs 57.7%, adjusted OR (95% CI) = 1.25 (0.84– 1.84), P = 0.270) and in the ≥ 38 years subgroup (14.0% vs 19.5%, adjusted OR (95% CI) = 1.09 (0.41– 2.92), P = 0.866), respectively. Nonetheless, the PGT group had a lower first-time biochemical pregnancy loss rate (17.0% vs 8.7%, P = 0.034) and a higher cumulative good birth outcome rate (35.2% vs 46.4%, P = 0.014) than the IVF/ICSI group in the < 38 years subgroup. Other pregnancy outcomes after the initial embryo transfer and multiple transfers following a single oocyte retrieval were all similar between groups.Conclusion: Our results showed no evidence of favorable effects of PGT-A treatment on improving the cumulative live birth rate in uRIF couples regardless of maternal age. Use of PGT-A in the < 38 years uRIF patients would help to decrease the first-time biochemical pregnancy loss and increase the cumulative good birth outcome.Keywords: preimplantation genetic testing for aneuploidy, unexplained recurrent implantation failure, cumulative live-birth rate, cumulative good birth outcomehttps://www.dovepress.com/preimplantation-genetic-testing-for-aneuploidy-could-not-improve-cumul-peer-reviewed-fulltext-article-TACGpreimplantation genetic testing for aneuploidyunexplained recurrent implantation failurecumulative live-birth ratecumulative good birth outcome |
| spellingShingle | Liu Y Lan X Lu J Zhang Q Zhou T Ni T Yan J Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation Failure The Application of Clinical Genetics preimplantation genetic testing for aneuploidy unexplained recurrent implantation failure cumulative live-birth rate cumulative good birth outcome |
| title | Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation Failure |
| title_full | Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation Failure |
| title_fullStr | Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation Failure |
| title_full_unstemmed | Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation Failure |
| title_short | Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation Failure |
| title_sort | preimplantation genetic testing for aneuploidy could not improve cumulative live birth rate among 705 couples with unexplained recurrent implantation failure |
| topic | preimplantation genetic testing for aneuploidy unexplained recurrent implantation failure cumulative live-birth rate cumulative good birth outcome |
| url | https://www.dovepress.com/preimplantation-genetic-testing-for-aneuploidy-could-not-improve-cumul-peer-reviewed-fulltext-article-TACG |
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