Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia
Background: Leukoplakia is a common, potentially premalignant lesion with malignant transformation rate from 1 to 17% with highest transformation rate for the lesions on the floor of the mouth, soft palate and tongue. One of the main etiological factors is consuming areca nut and its commercial prep...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Dental Research Journal |
| Subjects: | |
| Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2012;volume=9;issue=2;spage=158;epage=161;aulast=Bose |
| _version_ | 1819212789787394048 |
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| author | Subhash Chandra Bose Manishi Singh Prerna Vyas Manika Singh |
| author_facet | Subhash Chandra Bose Manishi Singh Prerna Vyas Manika Singh |
| author_sort | Subhash Chandra Bose |
| collection | DOAJ |
| description | Background: Leukoplakia is a common, potentially premalignant lesion with malignant transformation rate from 1 to 17% with highest transformation rate for the lesions on the floor of the mouth, soft palate and tongue. One of the main etiological factors is consuming areca nut and its commercial preparations which generate high levels of reactive oxygen species during their metabolism. So the aim of this present study is to evaluate the plasma levels of antioxidant vitamins, antioxidant mineral zinc, glutathione and total antioxidant status (TAS) in leukoplakia patients.
Materials and Methods: For this cross-sectional study, we selected 23 newly diagnosed oral leukoplakia patients of both sexes within the age group 28-40 years and the same number of age and sex matched healthy individuals without having history of any systemic illness were selected as control group. In both the groups, we measured plasma antioxidant vitamins A, C, E, antioxidant mineral zinc, GSH and TAS. Student′s t test was applied and the P value <0.001 was considered as statistically significant.
Results: We observed very low levels of antioxidant vitamins A, C, E, antioxidant mineral zinc and antioxidant metabolite GSH (P<0.001) and at the same time we also observed very poor (TAS) (P<0.001) in leukoplakia patients when compared to patients in control group.
Conclusion: The consumption of tobacco or areca quid which contains high copper levels creates an oxidative stress like environment during their metabolism, might play a major role in causation and propagation of oral leukoplakia. |
| first_indexed | 2024-12-23T06:48:33Z |
| format | Article |
| id | doaj.art-b6a3216dbbc2482e930d1b924e131c5a |
| institution | Directory Open Access Journal |
| issn | 1735-3327 2008-0255 |
| language | English |
| last_indexed | 2024-12-23T06:48:33Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Research Journal |
| spelling | doaj.art-b6a3216dbbc2482e930d1b924e131c5a2022-12-21T17:56:30ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552012-01-019215816110.4103/1735-3327.95229Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakiaSubhash Chandra BoseManishi SinghPrerna VyasManika SinghBackground: Leukoplakia is a common, potentially premalignant lesion with malignant transformation rate from 1 to 17% with highest transformation rate for the lesions on the floor of the mouth, soft palate and tongue. One of the main etiological factors is consuming areca nut and its commercial preparations which generate high levels of reactive oxygen species during their metabolism. So the aim of this present study is to evaluate the plasma levels of antioxidant vitamins, antioxidant mineral zinc, glutathione and total antioxidant status (TAS) in leukoplakia patients. Materials and Methods: For this cross-sectional study, we selected 23 newly diagnosed oral leukoplakia patients of both sexes within the age group 28-40 years and the same number of age and sex matched healthy individuals without having history of any systemic illness were selected as control group. In both the groups, we measured plasma antioxidant vitamins A, C, E, antioxidant mineral zinc, GSH and TAS. Student′s t test was applied and the P value <0.001 was considered as statistically significant. Results: We observed very low levels of antioxidant vitamins A, C, E, antioxidant mineral zinc and antioxidant metabolite GSH (P<0.001) and at the same time we also observed very poor (TAS) (P<0.001) in leukoplakia patients when compared to patients in control group. Conclusion: The consumption of tobacco or areca quid which contains high copper levels creates an oxidative stress like environment during their metabolism, might play a major role in causation and propagation of oral leukoplakia.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2012;volume=9;issue=2;spage=158;epage=161;aulast=BoseAntioxidantsfree radicalsleukoplakiazinc |
| spellingShingle | Subhash Chandra Bose Manishi Singh Prerna Vyas Manika Singh Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia Dental Research Journal Antioxidants free radicals leukoplakia zinc |
| title | Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia |
| title_full | Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia |
| title_fullStr | Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia |
| title_full_unstemmed | Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia |
| title_short | Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia |
| title_sort | plasma zinc antioxidant vitamins glutathione levels and total antioxidant activity in oral leukoplakia |
| topic | Antioxidants free radicals leukoplakia zinc |
| url | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2012;volume=9;issue=2;spage=158;epage=161;aulast=Bose |
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