CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance.

CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance.

Current thinking emphasizes the primacy of CD14 in facilitating recognition of microbes by certain TLRs to initiate pro-inflammatory signaling events and the importance of p38-MAPK in augmenting such responses. Herein, this paradigm is challenged by demonstrating that recognition of live Borrelia bu...

Full description

Bibliographic Details
Main Authors: Bikash Sahay, Rebeca L Patsey, Christian H Eggers, Juan C Salazar, Justin D Radolf, Timothy J Sellati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2781632?pdf=render

Similar Items

Similar Items