Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report
Abstract Background Proton pump inhibitors are frequently used (and often overused) medications with adverse effects including vitamin B12 deficiency, Clostridium difficile colitis, and increased risk of chronic kidney disease. Erectile dysfunction is largely unrecognized as an adverse effect of pro...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-021-02981-5 |
| _version_ | 1818657945797263360 |
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| author | Theodore W. Perry |
| author_facet | Theodore W. Perry |
| author_sort | Theodore W. Perry |
| collection | DOAJ |
| description | Abstract Background Proton pump inhibitors are frequently used (and often overused) medications with adverse effects including vitamin B12 deficiency, Clostridium difficile colitis, and increased risk of chronic kidney disease. Erectile dysfunction is largely unrecognized as an adverse effect of proton pump inhibitors despite increasing evidence that proton pump inhibitors may contribute to impaired nitric oxide generation and endothelial dysfunction. Case presentation A 38-year-old Caucasian man with mild hypertension and no other significant medical history developed profound erectile dysfunction within 2 days of initiating over-the-counter omeprazole therapy, with erectile function rapidly normalizing following discontinuation of the drug. At the time of the episode, the patient was on a stable dose of lisinopril and was taking no other medications or supplements. In the 2 years following the episode, the patient has had no further erectile difficulties. Conclusion Further study of erectile dysfunction as an adverse effect of proton pump inhibitors is needed. In the meantime, proton pump inhibitors should be considered as a potential cause of erectile dysfunction in healthy young patients and as a cause or contributor to erectile dysfunction in older patients in whom erectile dysfunction is often attributed to age or comorbidities. |
| first_indexed | 2024-12-17T03:49:33Z |
| format | Article |
| id | doaj.art-b6a53a8ba1e14a3ebef242f4c37eba52 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-17T03:49:33Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-b6a53a8ba1e14a3ebef242f4c37eba522022-12-21T22:04:47ZengBMCJournal of Medical Case Reports1752-19472021-07-011511310.1186/s13256-021-02981-5Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case reportTheodore W. Perry0North Texas VA Medical CenterAbstract Background Proton pump inhibitors are frequently used (and often overused) medications with adverse effects including vitamin B12 deficiency, Clostridium difficile colitis, and increased risk of chronic kidney disease. Erectile dysfunction is largely unrecognized as an adverse effect of proton pump inhibitors despite increasing evidence that proton pump inhibitors may contribute to impaired nitric oxide generation and endothelial dysfunction. Case presentation A 38-year-old Caucasian man with mild hypertension and no other significant medical history developed profound erectile dysfunction within 2 days of initiating over-the-counter omeprazole therapy, with erectile function rapidly normalizing following discontinuation of the drug. At the time of the episode, the patient was on a stable dose of lisinopril and was taking no other medications or supplements. In the 2 years following the episode, the patient has had no further erectile difficulties. Conclusion Further study of erectile dysfunction as an adverse effect of proton pump inhibitors is needed. In the meantime, proton pump inhibitors should be considered as a potential cause of erectile dysfunction in healthy young patients and as a cause or contributor to erectile dysfunction in older patients in whom erectile dysfunction is often attributed to age or comorbidities.https://doi.org/10.1186/s13256-021-02981-5Proton pump inhibitorOmeprazoleErectile dysfunctionEndothelial dysfunctionCase report |
| spellingShingle | Theodore W. Perry Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report Journal of Medical Case Reports Proton pump inhibitor Omeprazole Erectile dysfunction Endothelial dysfunction Case report |
| title | Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report |
| title_full | Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report |
| title_fullStr | Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report |
| title_full_unstemmed | Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report |
| title_short | Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report |
| title_sort | abrupt onset profound erectile dysfunction in a healthy young man after initiating over the counter omeprazole a case report |
| topic | Proton pump inhibitor Omeprazole Erectile dysfunction Endothelial dysfunction Case report |
| url | https://doi.org/10.1186/s13256-021-02981-5 |
| work_keys_str_mv | AT theodorewperry abruptonsetprofounderectiledysfunctioninahealthyyoungmanafterinitiatingoverthecounteromeprazoleacasereport |