Association between urinary phthalate levels and chronic pain in US adults, 1999–2004: A nationally representative survey
IntroductionChronic pain is a public health concern throughout the world. Ascertaining and managing its risk factors helps develop well-directed treatment plans and prevention strategies. Phthalates (PAEs) exposure leads to various health problems. The present study aims to explore the potential cor...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.940378/full |
| _version_ | 1797935055758163968 |
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| author | Guoping Jin Yaoyao Nie Jiayao Fan Ye Yang Dingwan Chen Yingjun Li Li Ju |
| author_facet | Guoping Jin Yaoyao Nie Jiayao Fan Ye Yang Dingwan Chen Yingjun Li Li Ju |
| author_sort | Guoping Jin |
| collection | DOAJ |
| description | IntroductionChronic pain is a public health concern throughout the world. Ascertaining and managing its risk factors helps develop well-directed treatment plans and prevention strategies. Phthalates (PAEs) exposure leads to various health problems. The present study aims to explore the potential correlation between urinary PAEs metabolites and chronic pain in adults.MethodsThe study population data were extracted from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004 in the United States. Seven urinary PAEs metabolites were used to assess long-term PAEs exposure. The assessment of chronic pain was determined by a self-report questionnaire. Weighted analyses were conducted to consider the complex sampling design. Models were adjusted by demographic data and lifestyle factors. Urinary PAEs metabolites were assessed as both continuous and categorical variables. Tertile 1 was considered as the reference. Stratified analyses were performed by gender and pain site. All data analyses were conducted with STATA, version 15.1. P < 0.05 was considered with statistical significance.ResultsA total of 4,196 participants were considered in our final analysis. Chronic pain prevalence reached 52.19% (n = 2,138) among the participants, with women accounting for a large proportion (57.75% vs. 42.25%). After multivariable logistic regression analysis, a higher prevalence of chronic pain was observed among participants in the third tertile of mono-(2-ethyl)-hexyl phthalate (MEHP) (OR = 1.23, 95% CI = 1.02–1.48, P = 0.034) and mono-benzyl phthalate (MBzP) (OR = 1.28, 95% CI = 1.04–1.58, P = 0.022) in our adjusted model. The logtransformed concentration of MBzP also showed a significant association with chronic pain prevalence (OR = 1.09, 95% CI = 1.01–1.18, P = 0.036) in the adjusted model. In further analysis, the positive correlations of urinary phthalate metabolites with chronic pain remained robust when stratified by gender and chronic pain site.ConclusionsOur findings presented a positive correlation between urinary PAEs metabolites and chronic pain among adult participants, and more causal research should be conducted to ascertain the interactions between the two and to expound their underlying mechanisms. |
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| id | doaj.art-b6a55e0cfc7649e3b96b45b28b5ac8c0 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T18:08:32Z |
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| series | Frontiers in Neurology |
| spelling | doaj.art-b6a55e0cfc7649e3b96b45b28b5ac8c02023-02-02T11:53:59ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-02-011410.3389/fneur.2023.940378940378Association between urinary phthalate levels and chronic pain in US adults, 1999–2004: A nationally representative surveyGuoping Jin0Yaoyao Nie1Jiayao Fan2Ye Yang3Dingwan Chen4Yingjun Li5Li Ju6Department of Orthopaedics, Ningbo No. 9 Hospital, Ningbo, Zhejiang, ChinaSchool of Public Health, Hangzhou Medical College, Hangzhou, ChinaSchool of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaSchool of Public Health, Hangzhou Medical College, Hangzhou, ChinaSchool of Public Health, Hangzhou Medical College, Hangzhou, ChinaSchool of Public Health, Hangzhou Medical College, Hangzhou, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Hangzhou Medical College, Hangzhou, ChinaIntroductionChronic pain is a public health concern throughout the world. Ascertaining and managing its risk factors helps develop well-directed treatment plans and prevention strategies. Phthalates (PAEs) exposure leads to various health problems. The present study aims to explore the potential correlation between urinary PAEs metabolites and chronic pain in adults.MethodsThe study population data were extracted from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004 in the United States. Seven urinary PAEs metabolites were used to assess long-term PAEs exposure. The assessment of chronic pain was determined by a self-report questionnaire. Weighted analyses were conducted to consider the complex sampling design. Models were adjusted by demographic data and lifestyle factors. Urinary PAEs metabolites were assessed as both continuous and categorical variables. Tertile 1 was considered as the reference. Stratified analyses were performed by gender and pain site. All data analyses were conducted with STATA, version 15.1. P < 0.05 was considered with statistical significance.ResultsA total of 4,196 participants were considered in our final analysis. Chronic pain prevalence reached 52.19% (n = 2,138) among the participants, with women accounting for a large proportion (57.75% vs. 42.25%). After multivariable logistic regression analysis, a higher prevalence of chronic pain was observed among participants in the third tertile of mono-(2-ethyl)-hexyl phthalate (MEHP) (OR = 1.23, 95% CI = 1.02–1.48, P = 0.034) and mono-benzyl phthalate (MBzP) (OR = 1.28, 95% CI = 1.04–1.58, P = 0.022) in our adjusted model. The logtransformed concentration of MBzP also showed a significant association with chronic pain prevalence (OR = 1.09, 95% CI = 1.01–1.18, P = 0.036) in the adjusted model. In further analysis, the positive correlations of urinary phthalate metabolites with chronic pain remained robust when stratified by gender and chronic pain site.ConclusionsOur findings presented a positive correlation between urinary PAEs metabolites and chronic pain among adult participants, and more causal research should be conducted to ascertain the interactions between the two and to expound their underlying mechanisms.https://www.frontiersin.org/articles/10.3389/fneur.2023.940378/fullphthalateschronic painNHANESepidemiologyplasticizers |
| spellingShingle | Guoping Jin Yaoyao Nie Jiayao Fan Ye Yang Dingwan Chen Yingjun Li Li Ju Association between urinary phthalate levels and chronic pain in US adults, 1999–2004: A nationally representative survey Frontiers in Neurology phthalates chronic pain NHANES epidemiology plasticizers |
| title | Association between urinary phthalate levels and chronic pain in US adults, 1999–2004: A nationally representative survey |
| title_full | Association between urinary phthalate levels and chronic pain in US adults, 1999–2004: A nationally representative survey |
| title_fullStr | Association between urinary phthalate levels and chronic pain in US adults, 1999–2004: A nationally representative survey |
| title_full_unstemmed | Association between urinary phthalate levels and chronic pain in US adults, 1999–2004: A nationally representative survey |
| title_short | Association between urinary phthalate levels and chronic pain in US adults, 1999–2004: A nationally representative survey |
| title_sort | association between urinary phthalate levels and chronic pain in us adults 1999 2004 a nationally representative survey |
| topic | phthalates chronic pain NHANES epidemiology plasticizers |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.940378/full |
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