Blood purification in two patients with clinically amyopathic dermatomyositis associated with interstitial lung disease with anti-melanoma differentiation-associated gene-5 antibody (MDA-5)
Patients of clinically amyopathic dermatomyositis associated with rapidly progressive interstitial pneumonia (CADM-RFIP) with positive anti-MDA5 antibody usually presents rapid deterioration and traditional therapy such as cyclophosphamide combined with high-dose prednisone pulse therapy shows no cl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-01-01
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| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007119301728 |
| _version_ | 1828482601085566976 |
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| author | Han-yu Shi Xue-ren Li Lu-qing Wei Shou-chun Peng |
| author_facet | Han-yu Shi Xue-ren Li Lu-qing Wei Shou-chun Peng |
| author_sort | Han-yu Shi |
| collection | DOAJ |
| description | Patients of clinically amyopathic dermatomyositis associated with rapidly progressive interstitial pneumonia (CADM-RFIP) with positive anti-MDA5 antibody usually presents rapid deterioration and traditional therapy such as cyclophosphamide combined with high-dose prednisone pulse therapy shows no clear benefit at whiles. However, blood purification combined with traditional therapy works according to the literature. We herein report two CADM-RFIP patients administered with DNA immunoadsorption combined with traditional therapy and then reviewed the literature of blood purification in CADM-RFIP patients at home and abroad to date. We emphasize blood purification such as DNA immunoadsorption could apply in the early stage of CADM-RFIP, which can decrease inflammation and allow us more time to control the condition better. Keywords: anti-MDA5 body, CADM, DNA immunoadsorption, Interstitial lung disease |
| first_indexed | 2024-12-11T08:17:51Z |
| format | Article |
| id | doaj.art-b6a740ebf61e4c7fa7a48349769ea05a |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-11T08:17:51Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-b6a740ebf61e4c7fa7a48349769ea05a2022-12-22T01:14:43ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-0128Blood purification in two patients with clinically amyopathic dermatomyositis associated with interstitial lung disease with anti-melanoma differentiation-associated gene-5 antibody (MDA-5)Han-yu Shi0Xue-ren Li1Lu-qing Wei2Shou-chun Peng3Department of Respiratory and Critical Care Medicine, Special Medical Center of Chinese People's Armed Police Force, Tianjin, 300309, China; Logistics University of Chinese People's Armed Police Force, Tianjin, 300309, ChinaDepartment of Respiratory and Critical Care Medicine, Special Medical Center of Chinese People's Armed Police Force, Tianjin, 300309, ChinaDepartment of Respiratory and Critical Care Medicine, Special Medical Center of Chinese People's Armed Police Force, Tianjin, 300309, China; Corresponding author.Department of Respiratory and Critical Care Medicine, Special Medical Center of Chinese People's Armed Police Force, Tianjin, 300309, China; Corresponding author.Patients of clinically amyopathic dermatomyositis associated with rapidly progressive interstitial pneumonia (CADM-RFIP) with positive anti-MDA5 antibody usually presents rapid deterioration and traditional therapy such as cyclophosphamide combined with high-dose prednisone pulse therapy shows no clear benefit at whiles. However, blood purification combined with traditional therapy works according to the literature. We herein report two CADM-RFIP patients administered with DNA immunoadsorption combined with traditional therapy and then reviewed the literature of blood purification in CADM-RFIP patients at home and abroad to date. We emphasize blood purification such as DNA immunoadsorption could apply in the early stage of CADM-RFIP, which can decrease inflammation and allow us more time to control the condition better. Keywords: anti-MDA5 body, CADM, DNA immunoadsorption, Interstitial lung diseasehttp://www.sciencedirect.com/science/article/pii/S2213007119301728 |
| spellingShingle | Han-yu Shi Xue-ren Li Lu-qing Wei Shou-chun Peng Blood purification in two patients with clinically amyopathic dermatomyositis associated with interstitial lung disease with anti-melanoma differentiation-associated gene-5 antibody (MDA-5) Respiratory Medicine Case Reports |
| title | Blood purification in two patients with clinically amyopathic dermatomyositis associated with interstitial lung disease with anti-melanoma differentiation-associated gene-5 antibody (MDA-5) |
| title_full | Blood purification in two patients with clinically amyopathic dermatomyositis associated with interstitial lung disease with anti-melanoma differentiation-associated gene-5 antibody (MDA-5) |
| title_fullStr | Blood purification in two patients with clinically amyopathic dermatomyositis associated with interstitial lung disease with anti-melanoma differentiation-associated gene-5 antibody (MDA-5) |
| title_full_unstemmed | Blood purification in two patients with clinically amyopathic dermatomyositis associated with interstitial lung disease with anti-melanoma differentiation-associated gene-5 antibody (MDA-5) |
| title_short | Blood purification in two patients with clinically amyopathic dermatomyositis associated with interstitial lung disease with anti-melanoma differentiation-associated gene-5 antibody (MDA-5) |
| title_sort | blood purification in two patients with clinically amyopathic dermatomyositis associated with interstitial lung disease with anti melanoma differentiation associated gene 5 antibody mda 5 |
| url | http://www.sciencedirect.com/science/article/pii/S2213007119301728 |
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