Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos
Taraxaci folium and Matricariae flos plant extracts contain a wide range of bioactive compounds with antioxidant and anti-inflammatory effects. The aim of the study was to evaluate the phytochemical and antioxidant profile of the two plant extracts to obtain a mucoadhesive polymeric film with benefi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/10/4002 |
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| author | Oana Mihaela Neagu Timea Ghitea Eleonora Marian Laurian Vlase Ana-Maria Vlase Gabriela Ciavoi Pálma Fehér Annamária Pallag Ildikó Bácskay Dániel Nemes Laura Grațiela Vicaș Alin Teușdea Tünde Jurca |
| author_facet | Oana Mihaela Neagu Timea Ghitea Eleonora Marian Laurian Vlase Ana-Maria Vlase Gabriela Ciavoi Pálma Fehér Annamária Pallag Ildikó Bácskay Dániel Nemes Laura Grațiela Vicaș Alin Teușdea Tünde Jurca |
| author_sort | Oana Mihaela Neagu |
| collection | DOAJ |
| description | Taraxaci folium and Matricariae flos plant extracts contain a wide range of bioactive compounds with antioxidant and anti-inflammatory effects. The aim of the study was to evaluate the phytochemical and antioxidant profile of the two plant extracts to obtain a mucoadhesive polymeric film with beneficial properties in acute gingivitis. The chemical composition of the two plant extracts was determined by high-performance liquid chromatography coupled with mass spectrometry. To establish a favourable ratio in the combination of the two extracts, the antioxidant capacity was determined by the method of reduction of copper ions Cu<sup>2+</sup> from neocuprein and by reduction of the compound 1.1-diphenyl-2-2picril-hydrazyl. Following preliminary analysis, we selected the plant mixture Taraxaci folium/matricariae flos in the ratio of 1:2 (<i>m</i>/<i>m</i>), having an antioxidant capacity of 83.92% ± 0.02 reduction of free nitrogen radical of 1.1-diphenyl-2-2picril-hydrazyl reagent. Subsequently, bioadhesive films of 0.2 mm thickness were obtained using various concentrations of polymer and plant extract. The mucoadhesive films obtained were homogeneous and flexible, with pH ranging from 6.634 to 7.016 and active ingredient release capacity ranging from 85.94–89.52%. Based on in vitro analysis, the film containing 5% polymer and 10% plant extract was selected for in vivo study. The study involved 50 patients undergoing professional oral hygiene followed by a 7-day treatment with the chosen mucoadhesive polymeric film. The study showed that the film used helped accelerate the healing of acute gingivitis after treatment, with anti-inflammatory and protective action. |
| first_indexed | 2024-03-11T03:27:40Z |
| format | Article |
| id | doaj.art-b6a8bf7a4f00441f9eed473147d96684 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:27:40Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b6a8bf7a4f00441f9eed473147d966842023-11-18T02:37:54ZengMDPI AGMolecules1420-30492023-05-012810400210.3390/molecules28104002Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae FlosOana Mihaela Neagu0Timea Ghitea1Eleonora Marian2Laurian Vlase3Ana-Maria Vlase4Gabriela Ciavoi5Pálma Fehér6Annamária Pallag7Ildikó Bácskay8Dániel Nemes9Laura Grațiela Vicaș10Alin Teușdea11Tünde Jurca12Doctoral School of Biomedical Sciences, University of Oradea, 1 Universității Street, 410073 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410028 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410028 Oradea, RomaniaDepartment of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy, 8 Victor Babeș Street, 400347 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and Pharmacy, 8 Victor Babeș Street, 400347 Cluj-Napoca, RomaniaDental Medicine Department, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, RomaniaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410028 Oradea, RomaniaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410028 Oradea, RomaniaFaculty of Environmental Protection, University of Oradea, No. 26 General Magheru Avenue, 410087 Oradea, RomaniaDoctoral School of Biomedical Sciences, University of Oradea, 1 Universității Street, 410073 Oradea, RomaniaTaraxaci folium and Matricariae flos plant extracts contain a wide range of bioactive compounds with antioxidant and anti-inflammatory effects. The aim of the study was to evaluate the phytochemical and antioxidant profile of the two plant extracts to obtain a mucoadhesive polymeric film with beneficial properties in acute gingivitis. The chemical composition of the two plant extracts was determined by high-performance liquid chromatography coupled with mass spectrometry. To establish a favourable ratio in the combination of the two extracts, the antioxidant capacity was determined by the method of reduction of copper ions Cu<sup>2+</sup> from neocuprein and by reduction of the compound 1.1-diphenyl-2-2picril-hydrazyl. Following preliminary analysis, we selected the plant mixture Taraxaci folium/matricariae flos in the ratio of 1:2 (<i>m</i>/<i>m</i>), having an antioxidant capacity of 83.92% ± 0.02 reduction of free nitrogen radical of 1.1-diphenyl-2-2picril-hydrazyl reagent. Subsequently, bioadhesive films of 0.2 mm thickness were obtained using various concentrations of polymer and plant extract. The mucoadhesive films obtained were homogeneous and flexible, with pH ranging from 6.634 to 7.016 and active ingredient release capacity ranging from 85.94–89.52%. Based on in vitro analysis, the film containing 5% polymer and 10% plant extract was selected for in vivo study. The study involved 50 patients undergoing professional oral hygiene followed by a 7-day treatment with the chosen mucoadhesive polymeric film. The study showed that the film used helped accelerate the healing of acute gingivitis after treatment, with anti-inflammatory and protective action.https://www.mdpi.com/1420-3049/28/10/4002Taraxaci foliummatricariae flosantioxidantsanti-inflammatorygingivitisbioadhesive film |
| spellingShingle | Oana Mihaela Neagu Timea Ghitea Eleonora Marian Laurian Vlase Ana-Maria Vlase Gabriela Ciavoi Pálma Fehér Annamária Pallag Ildikó Bácskay Dániel Nemes Laura Grațiela Vicaș Alin Teușdea Tünde Jurca Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos Molecules Taraxaci folium matricariae flos antioxidants anti-inflammatory gingivitis bioadhesive film |
| title | Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos |
| title_full | Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos |
| title_fullStr | Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos |
| title_full_unstemmed | Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos |
| title_short | Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos |
| title_sort | formulation and characterization of mucoadhesive polymeric films containing extracts of taraxaci folium and matricariae flos |
| topic | Taraxaci folium matricariae flos antioxidants anti-inflammatory gingivitis bioadhesive film |
| url | https://www.mdpi.com/1420-3049/28/10/4002 |
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