Trabecular bone density in middle-aged women with reproductive disorders
Besides age, estrogen exposure plays a crucial role in changes in bone density (BD) in women. Premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are conditions in reproductive-aged women in which the exposure to estrogen is substantially different. Women with a history of pre...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-10-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/12/11/EC-23-0166.xml |
| _version_ | 1797665895438352384 |
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| author | Charissa van Zwol-Janssens Aglaia Hage Kim van der Ham Birgitta K Velthuis Ricardo P J Budde Maria P H Koster Arie Franx Bart C J M Fauser Eric Boersma Daniel Bos Joop S E Laven Yvonne V Louwers |
| author_facet | Charissa van Zwol-Janssens Aglaia Hage Kim van der Ham Birgitta K Velthuis Ricardo P J Budde Maria P H Koster Arie Franx Bart C J M Fauser Eric Boersma Daniel Bos Joop S E Laven Yvonne V Louwers |
| author_sort | Charissa van Zwol-Janssens |
| collection | DOAJ |
| description | Besides age, estrogen exposure plays a crucial role in changes in bone density (BD) in women. Premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are conditions in reproductive-aged women in which the exposure to estrogen is substantially different. Women with a history of preeclampsia (P E) are expected to have normal estrogen exposure. Within the CREw IMAGO study, we investigated if trabecular BD is different in these women because of differences in the duration of estrogen exposure. Trabecular BD was measured in thoracic vertebrae on coronary CT scans. Women with a reduced estrogen exposure (POI) have a lower BD compared to women with an intermediate exposure (PE) (mean difference (MD) −26.8, 95% CI −37.2 to −16.3). Women with a prolonged estrogen exposure (PCOS) have the highest BD (MD 15.0, 95% CI 4.3–25.7). These results support the hypothesis that the duration of estrogen exposure in these women is associated with trabecular BD.
Significance statement: Our results suggest that middle-aged women with PCOS have a higher BD and women with POI have a lower BD. We hypothesized that this is due to either a prolonged estrogen exposure, as seen in women with PCOS, or a reduced estrogen exposure, as in women with POI. In the counseling of women with reproductive disorders on long-term health issues, coronary CT provides a unique opportunity to assess both coronary artery calcium score for cardiovascular screening as w ell as trabecular BD. |
| first_indexed | 2024-03-11T19:50:41Z |
| format | Article |
| id | doaj.art-b6a91f11ea4c4af6a03f400754a06d2b |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-03-11T19:50:41Z |
| publishDate | 2023-10-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-b6a91f11ea4c4af6a03f400754a06d2b2023-10-05T09:57:25ZengBioscientificaEndocrine Connections2049-36142023-10-01121115https://doi.org/10.1530/EC-23-0166Trabecular bone density in middle-aged women with reproductive disordersCharissa van Zwol-Janssens0Aglaia Hage1Kim van der Ham2Birgitta K Velthuis3Ricardo P J Budde4Maria P H Koster5Arie Franx6Bart C J M Fauser7Eric Boersma8Daniel Bos9Joop S E Laven10Yvonne V Louwers11Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the NetherlandsDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the NetherlandsDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Radiology, University Medical Center Utrecht, University of Utrecht, Utrecht, the NetherlandsDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the NetherlandsDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Reproductive Medicine and Gynaecology, University Medical Center Utrecht & University of Utrecht, Utrecht, the NetherlandsDepartment of Cardiology, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the NetherlandsDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the NetherlandsBesides age, estrogen exposure plays a crucial role in changes in bone density (BD) in women. Premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are conditions in reproductive-aged women in which the exposure to estrogen is substantially different. Women with a history of preeclampsia (P E) are expected to have normal estrogen exposure. Within the CREw IMAGO study, we investigated if trabecular BD is different in these women because of differences in the duration of estrogen exposure. Trabecular BD was measured in thoracic vertebrae on coronary CT scans. Women with a reduced estrogen exposure (POI) have a lower BD compared to women with an intermediate exposure (PE) (mean difference (MD) −26.8, 95% CI −37.2 to −16.3). Women with a prolonged estrogen exposure (PCOS) have the highest BD (MD 15.0, 95% CI 4.3–25.7). These results support the hypothesis that the duration of estrogen exposure in these women is associated with trabecular BD. Significance statement: Our results suggest that middle-aged women with PCOS have a higher BD and women with POI have a lower BD. We hypothesized that this is due to either a prolonged estrogen exposure, as seen in women with PCOS, or a reduced estrogen exposure, as in women with POI. In the counseling of women with reproductive disorders on long-term health issues, coronary CT provides a unique opportunity to assess both coronary artery calcium score for cardiovascular screening as w ell as trabecular BD.https://ec.bioscientifica.com/view/journals/ec/12/11/EC-23-0166.xmlbone densitypremature ovarian insufficiencypreeclampsiapolycystic ovary syndrome |
| spellingShingle | Charissa van Zwol-Janssens Aglaia Hage Kim van der Ham Birgitta K Velthuis Ricardo P J Budde Maria P H Koster Arie Franx Bart C J M Fauser Eric Boersma Daniel Bos Joop S E Laven Yvonne V Louwers Trabecular bone density in middle-aged women with reproductive disorders Endocrine Connections bone density premature ovarian insufficiency preeclampsia polycystic ovary syndrome |
| title | Trabecular bone density in middle-aged women with reproductive disorders |
| title_full | Trabecular bone density in middle-aged women with reproductive disorders |
| title_fullStr | Trabecular bone density in middle-aged women with reproductive disorders |
| title_full_unstemmed | Trabecular bone density in middle-aged women with reproductive disorders |
| title_short | Trabecular bone density in middle-aged women with reproductive disorders |
| title_sort | trabecular bone density in middle aged women with reproductive disorders |
| topic | bone density premature ovarian insufficiency preeclampsia polycystic ovary syndrome |
| url | https://ec.bioscientifica.com/view/journals/ec/12/11/EC-23-0166.xml |
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