Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe<sub>3</sub>O<sub>4</sub> Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor
In recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/7/949 |
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| author | Itziar Galarreta-Rodriguez Mikel Etxebeste-Mitxeltorena Esther Moreno Daniel Plano Carmen Sanmartín Saad Megahed Neus Feliu Wolfgang J. Parak Eneko Garaio Izaskun Gil de Muro Luis Lezama Idoia Ruiz de Larramendi Maite Insausti |
| author_facet | Itziar Galarreta-Rodriguez Mikel Etxebeste-Mitxeltorena Esther Moreno Daniel Plano Carmen Sanmartín Saad Megahed Neus Feliu Wolfgang J. Parak Eneko Garaio Izaskun Gil de Muro Luis Lezama Idoia Ruiz de Larramendi Maite Insausti |
| author_sort | Itziar Galarreta-Rodriguez |
| collection | DOAJ |
| description | In recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailored to present a hyperthermia response, allowing for the design of multifunctional systems which can be active in therapies. In this work, we have designed a drug carrier nanosystem based on Fe<sub>3</sub>O<sub>4</sub> nanoparticles with large heating power and 4-amino-2-pentylselenoquinazoline as an attached drug that exhibits oxidative properties and high selectivity against a variety of cancer malignant cells. For this propose, two samples composed of homogeneous Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) with different sizes, shapes, and magnetic properties have been synthesised and characterised. The surface modification of the prepared Fe<sub>3</sub>O<sub>4</sub> nanoparticles has been developed using copolymers composed of poly(ethylene-alt-maleic anhydride), dodecylamine, polyethylene glycol and the drug 4-amino-2-pentylselenoquinazoline. The obtained nanosystems were properly characterised. Their in vitro efficacy in colon cancer cells and as magnetic hyperthermia inductors was analysed, thereby leaving the door open for their potential application as multimodal agents. |
| first_indexed | 2024-03-11T00:45:12Z |
| format | Article |
| id | doaj.art-b6a9dc3904f14c1e9b45c9c6c95e865e |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T00:45:12Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-b6a9dc3904f14c1e9b45c9c6c95e865e2023-11-18T20:52:14ZengMDPI AGPharmaceuticals1424-82472023-06-0116794910.3390/ph16070949Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe<sub>3</sub>O<sub>4</sub> Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia InductorItziar Galarreta-Rodriguez0Mikel Etxebeste-Mitxeltorena1Esther Moreno2Daniel Plano3Carmen Sanmartín4Saad Megahed5Neus Feliu6Wolfgang J. Parak7Eneko Garaio8Izaskun Gil de Muro9Luis Lezama10Idoia Ruiz de Larramendi11Maite Insausti12Departamento Química Orgánica e Inorgánica, Facultad de Ciencia y Tecnología, University of the Basque Country (UPV/EHU), Sarriena s/n, 48940 Leioa, SpainDepartment of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, 31008 Pamplona, SpainTropical Health Institute of the University of Navarra (ISTUN), University of Navarra, Irunlarrea 1, 31008 Pamplona, SpainDepartment of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, 31008 Pamplona, SpainDepartment of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, 31008 Pamplona, SpainFachbereich Physik, Universität Hamburg, 22761 Hamburg, GermanyCenter for Applied Nanotechnology CAN, Fraunhofer Institute for Applied Polymer Research IAP, 20146 Hamburg, GermanyFachbereich Physik, Universität Hamburg, 22761 Hamburg, GermanyDepartamento de Ciencias, Universidad Pública de Navarra, Campus Arrosadía, 31006 Pamplona, SpainDepartamento Química Orgánica e Inorgánica, Facultad de Ciencia y Tecnología, University of the Basque Country (UPV/EHU), Sarriena s/n, 48940 Leioa, SpainDepartamento Química Orgánica e Inorgánica, Facultad de Ciencia y Tecnología, University of the Basque Country (UPV/EHU), Sarriena s/n, 48940 Leioa, SpainDepartamento Química Orgánica e Inorgánica, Facultad de Ciencia y Tecnología, University of the Basque Country (UPV/EHU), Sarriena s/n, 48940 Leioa, SpainDepartamento Química Orgánica e Inorgánica, Facultad de Ciencia y Tecnología, University of the Basque Country (UPV/EHU), Sarriena s/n, 48940 Leioa, SpainIn recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailored to present a hyperthermia response, allowing for the design of multifunctional systems which can be active in therapies. In this work, we have designed a drug carrier nanosystem based on Fe<sub>3</sub>O<sub>4</sub> nanoparticles with large heating power and 4-amino-2-pentylselenoquinazoline as an attached drug that exhibits oxidative properties and high selectivity against a variety of cancer malignant cells. For this propose, two samples composed of homogeneous Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) with different sizes, shapes, and magnetic properties have been synthesised and characterised. The surface modification of the prepared Fe<sub>3</sub>O<sub>4</sub> nanoparticles has been developed using copolymers composed of poly(ethylene-alt-maleic anhydride), dodecylamine, polyethylene glycol and the drug 4-amino-2-pentylselenoquinazoline. The obtained nanosystems were properly characterised. Their in vitro efficacy in colon cancer cells and as magnetic hyperthermia inductors was analysed, thereby leaving the door open for their potential application as multimodal agents.https://www.mdpi.com/1424-8247/16/7/949magnetic nanoparticlesdrug carriersmagnetic hyperthermia inductor |
| spellingShingle | Itziar Galarreta-Rodriguez Mikel Etxebeste-Mitxeltorena Esther Moreno Daniel Plano Carmen Sanmartín Saad Megahed Neus Feliu Wolfgang J. Parak Eneko Garaio Izaskun Gil de Muro Luis Lezama Idoia Ruiz de Larramendi Maite Insausti Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe<sub>3</sub>O<sub>4</sub> Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor Pharmaceuticals magnetic nanoparticles drug carriers magnetic hyperthermia inductor |
| title | Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe<sub>3</sub>O<sub>4</sub> Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor |
| title_full | Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe<sub>3</sub>O<sub>4</sub> Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor |
| title_fullStr | Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe<sub>3</sub>O<sub>4</sub> Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor |
| title_full_unstemmed | Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe<sub>3</sub>O<sub>4</sub> Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor |
| title_short | Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe<sub>3</sub>O<sub>4</sub> Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor |
| title_sort | preparation of selenium based drug modified polymeric ligand functionalised fe sub 3 sub o sub 4 sub nanoparticles as multimodal drug carrier and magnetic hyperthermia inductor |
| topic | magnetic nanoparticles drug carriers magnetic hyperthermia inductor |
| url | https://www.mdpi.com/1424-8247/16/7/949 |
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