Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping review
Aim: Animal models of Extracorporeal Cardiopulmonary Resuscitation (ECPR) focusing on neurological outcomes are required to further the development of this potentially life-saving technology. The aim of this review is to summarize current animal models of ECPR. Methods: A comprehensive database sear...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Resuscitation Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666520423000693 |
| _version_ | 1797690882542010368 |
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| author | Shinichi Ijuin Keibun Liu Denzil Gill Sun Kyun Ro Jana Vukovic Satoshi Ishihara Jan Belohlavek Gianluigi Li Bassi Jacky Y Suen John F Fraser |
| author_facet | Shinichi Ijuin Keibun Liu Denzil Gill Sun Kyun Ro Jana Vukovic Satoshi Ishihara Jan Belohlavek Gianluigi Li Bassi Jacky Y Suen John F Fraser |
| author_sort | Shinichi Ijuin |
| collection | DOAJ |
| description | Aim: Animal models of Extracorporeal Cardiopulmonary Resuscitation (ECPR) focusing on neurological outcomes are required to further the development of this potentially life-saving technology. The aim of this review is to summarize current animal models of ECPR. Methods: A comprehensive database search of PubMed, EMBASE, and Web of Science was undertaken. Full-text publications describing animal models of ECPR between January 1, 2000, and June 30, 2022, were identified and included in the review. Data describing the conduct of the animal models of ECPR, measured variables, and outcomes were extracted according to pre-defined definitions. Results: The search strategy yielded 805 unique reports of which 37 studies were included in the final analysis. Most studies (95%) described using a pig model of ECPR with the remainder (5%) describing a rat model. The most common method for induction of cardiac arrest was a fatal ventricular arrhythmia through electrical stimulation (70%). 10 studies reported neurological assessment of animals using physical examination, serum biomarkers, or electrophysiological findings, however, only two studies described a multimodal assessment. No studies reported the use of brain imaging as part of the neurological assessment. Return of spontaneous circulation was the most reported primary outcome, and no studies described the neurological status of the animal as the primary outcome. Conclusion: Current animal models of ECPR do not describe clinically relevant neurological outcomes after cardiac arrest. Further work is needed to develop models that more accurately mimic clinical scenarios and can test innovations that can be translated to the application of ECPR in clinical medicine. |
| first_indexed | 2024-03-12T02:06:27Z |
| format | Article |
| id | doaj.art-b6aa3589f8fb4a29ace2da6e66488b7c |
| institution | Directory Open Access Journal |
| issn | 2666-5204 |
| language | English |
| last_indexed | 2024-03-12T02:06:27Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Resuscitation Plus |
| spelling | doaj.art-b6aa3589f8fb4a29ace2da6e66488b7c2023-09-07T04:44:53ZengElsevierResuscitation Plus2666-52042023-09-0115100426Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping reviewShinichi Ijuin0Keibun Liu1Denzil Gill2Sun Kyun Ro3Jana Vukovic4Satoshi Ishihara5Jan Belohlavek6Gianluigi Li Bassi7Jacky Y Suen8John F Fraser9Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia; Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center, Kobe, JapanCritical Care Research Group, The Prince Charles Hospital, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, AustraliaFaculty of Medicine, University of Queensland, Brisbane, Australia; Adult Intensive Care Services, The Prince Charles Hospital, Brisbane, AustraliaFaculty of Medicine, University of Queensland, Brisbane, Australia; Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center, Kobe, Japan; Department of Thoracic and Cardiovascular Surgery, Hanyang University Guri Hospital, Hanyang University College of Medicine, Seoul, Republic of KoreaSchool of Biomedical Sciences, University of Queensland, Brisbane, AustraliaDepartment of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center, Kobe, JapanSecond Department of Internal Medicine, Cardiovascular Medicine, General University Hospital and First Medical School, Charles University in Prague, Czech RepublicCritical Care Research Group, The Prince Charles Hospital, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia; Queensland University of Technology, Brisbane, AustraliaCritical Care Research Group, The Prince Charles Hospital, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, AustraliaCritical Care Research Group, The Prince Charles Hospital, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia; Adult Intensive Care Services, The Prince Charles Hospital, Brisbane, Australia; Queensland University of Technology, Brisbane, Australia; St. Andrews War Memorial Hospital, Brisbane, Australia; Corresponding author at: Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia; Address: Level 3, Clinical Sciences Building, Rode Road, Chermside Hospital, 4032 Brisbane, Australia.Aim: Animal models of Extracorporeal Cardiopulmonary Resuscitation (ECPR) focusing on neurological outcomes are required to further the development of this potentially life-saving technology. The aim of this review is to summarize current animal models of ECPR. Methods: A comprehensive database search of PubMed, EMBASE, and Web of Science was undertaken. Full-text publications describing animal models of ECPR between January 1, 2000, and June 30, 2022, were identified and included in the review. Data describing the conduct of the animal models of ECPR, measured variables, and outcomes were extracted according to pre-defined definitions. Results: The search strategy yielded 805 unique reports of which 37 studies were included in the final analysis. Most studies (95%) described using a pig model of ECPR with the remainder (5%) describing a rat model. The most common method for induction of cardiac arrest was a fatal ventricular arrhythmia through electrical stimulation (70%). 10 studies reported neurological assessment of animals using physical examination, serum biomarkers, or electrophysiological findings, however, only two studies described a multimodal assessment. No studies reported the use of brain imaging as part of the neurological assessment. Return of spontaneous circulation was the most reported primary outcome, and no studies described the neurological status of the animal as the primary outcome. Conclusion: Current animal models of ECPR do not describe clinically relevant neurological outcomes after cardiac arrest. Further work is needed to develop models that more accurately mimic clinical scenarios and can test innovations that can be translated to the application of ECPR in clinical medicine.http://www.sciencedirect.com/science/article/pii/S2666520423000693Extracorporeal cardiopulmonary resuscitationCardiac arrestAnimal modelNeurological assessmentScoping review |
| spellingShingle | Shinichi Ijuin Keibun Liu Denzil Gill Sun Kyun Ro Jana Vukovic Satoshi Ishihara Jan Belohlavek Gianluigi Li Bassi Jacky Y Suen John F Fraser Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping review Resuscitation Plus Extracorporeal cardiopulmonary resuscitation Cardiac arrest Animal model Neurological assessment Scoping review |
| title | Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping review |
| title_full | Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping review |
| title_fullStr | Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping review |
| title_full_unstemmed | Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping review |
| title_short | Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping review |
| title_sort | current animal models of extracorporeal cardiopulmonary resuscitation a scoping review |
| topic | Extracorporeal cardiopulmonary resuscitation Cardiac arrest Animal model Neurological assessment Scoping review |
| url | http://www.sciencedirect.com/science/article/pii/S2666520423000693 |
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