Coated microbubbles swim via shell buckling
Abstract Engineered microswimmers show great promise in various biomedical applications. However, their application is hindered by the slow mobility, limited maneuverability and poor biocompatibility. Lipid coated microbubbles have high compressibility and are already approved for clinical use as di...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
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| Series: | Communications Engineering |
| Online Access: | https://doi.org/10.1038/s44172-023-00113-z |
| _version_ | 1827710822809337856 |
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| author | Georges Chabouh Marcel Mokbel Benjamin van Elburg Michel Versluis Tim Segers Sebastian Aland Catherine Quilliet Gwennou Coupier |
| author_facet | Georges Chabouh Marcel Mokbel Benjamin van Elburg Michel Versluis Tim Segers Sebastian Aland Catherine Quilliet Gwennou Coupier |
| author_sort | Georges Chabouh |
| collection | DOAJ |
| description | Abstract Engineered microswimmers show great promise in various biomedical applications. However, their application is hindered by the slow mobility, limited maneuverability and poor biocompatibility. Lipid coated microbubbles have high compressibility and are already approved for clinical use as diagnostic ultrasound contrast agents. Here we experimentally investigate the swimming motion of these microbubbles under external cyclic overpressure. A net displacement was generated via reproducible and non-destructive cycles of deflation and re-inflation of the microbubble. We also propose a numerical model which allows a maximum swimming speed on the order of meters per second, which falls in the range of blood flow velocity in large vessels. Unlike the acoustic radiation force technique, where the displacement is always directed along the axis of ultrasound propagation, here, the direction of propulsion is controlled in the shell reference frame. This provides a solution toward controlled steering for ultrasound molecular imaging and drug delivery. |
| first_indexed | 2024-03-10T17:45:15Z |
| format | Article |
| id | doaj.art-b6ab9ec5456846968175e432f794564a |
| institution | Directory Open Access Journal |
| issn | 2731-3395 |
| language | English |
| last_indexed | 2024-03-10T17:45:15Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Engineering |
| spelling | doaj.art-b6ab9ec5456846968175e432f794564a2023-11-20T09:34:56ZengNature PortfolioCommunications Engineering2731-33952023-09-01211810.1038/s44172-023-00113-zCoated microbubbles swim via shell bucklingGeorges Chabouh0Marcel Mokbel1Benjamin van Elburg2Michel Versluis3Tim Segers4Sebastian Aland5Catherine Quilliet6Gwennou Coupier7CNRS/Université Grenoble-Alpes, LIPhy UMR 5588Technische Universität Bergakademie FreibergPhysics of Fluids Group, Technical Medical (TechMed) Center and MESA+ Institute for Nanotechnology, University of TwentePhysics of Fluids Group, Technical Medical (TechMed) Center and MESA+ Institute for Nanotechnology, University of TwenteBIOS/Lab-on-a-Chip Group, Max Planck Center Twente for Complex Fluid Dynamics, MESA+ Institute for Nanotechnology, University of TwenteTechnische Universität Bergakademie FreibergCNRS/Université Grenoble-Alpes, LIPhy UMR 5588CNRS/Université Grenoble-Alpes, LIPhy UMR 5588Abstract Engineered microswimmers show great promise in various biomedical applications. However, their application is hindered by the slow mobility, limited maneuverability and poor biocompatibility. Lipid coated microbubbles have high compressibility and are already approved for clinical use as diagnostic ultrasound contrast agents. Here we experimentally investigate the swimming motion of these microbubbles under external cyclic overpressure. A net displacement was generated via reproducible and non-destructive cycles of deflation and re-inflation of the microbubble. We also propose a numerical model which allows a maximum swimming speed on the order of meters per second, which falls in the range of blood flow velocity in large vessels. Unlike the acoustic radiation force technique, where the displacement is always directed along the axis of ultrasound propagation, here, the direction of propulsion is controlled in the shell reference frame. This provides a solution toward controlled steering for ultrasound molecular imaging and drug delivery.https://doi.org/10.1038/s44172-023-00113-z |
| spellingShingle | Georges Chabouh Marcel Mokbel Benjamin van Elburg Michel Versluis Tim Segers Sebastian Aland Catherine Quilliet Gwennou Coupier Coated microbubbles swim via shell buckling Communications Engineering |
| title | Coated microbubbles swim via shell buckling |
| title_full | Coated microbubbles swim via shell buckling |
| title_fullStr | Coated microbubbles swim via shell buckling |
| title_full_unstemmed | Coated microbubbles swim via shell buckling |
| title_short | Coated microbubbles swim via shell buckling |
| title_sort | coated microbubbles swim via shell buckling |
| url | https://doi.org/10.1038/s44172-023-00113-z |
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