Effects of acid-sensing ion channel-1A (ASIC1A) on cocaine-induced synaptic adaptations

Effects of acid-sensing ion channel-1A (ASIC1A) on cocaine-induced synaptic adaptations

Chronic drug abuse is thought to induce synaptic changes in nucleus accumbens medium spiny neurons (MSNs) that promote subsequent craving and drug-seeking behavior. Accumulating data suggest acid-sensing ion channels (ASICs) may play a critical role. In drug naïve mice, disrupting the ASIC1A subunit...

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Bibliographic Details
Main Authors: Subhash C. Gupta, Rebecca J. Taugher-Hebl, Jason B. Hardie, Rong Fan, Ryan T. LaLumiere, John A. Wemmie
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Physiology
Subjects:
cocaine
synaptic plasticity
ASIC1A
structural plasticity
nucleus accumben
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1191275/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1191275/full

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