Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis
BackgroundAlthough observational studies have shown that patients who experienced transient ischemic attacks (TIAs) had a higher risk of coronary artery disease (CAD), the causal relationship is ambiguous.MethodsWe conducted a two-sample Mendelian randomization (MR) study to analyze the causal relat...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1192664/full |
| _version_ | 1827863100082094080 |
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| author | Xiaoyi Qi Xiaoyi Qi Shijia Wang Liangxian Qiu Xiongbiao Chen Qianwen Huang Kunfu Ouyang Yanjun Chen |
| author_facet | Xiaoyi Qi Xiaoyi Qi Shijia Wang Liangxian Qiu Xiongbiao Chen Qianwen Huang Kunfu Ouyang Yanjun Chen |
| author_sort | Xiaoyi Qi |
| collection | DOAJ |
| description | BackgroundAlthough observational studies have shown that patients who experienced transient ischemic attacks (TIAs) had a higher risk of coronary artery disease (CAD), the causal relationship is ambiguous.MethodsWe conducted a two-sample Mendelian randomization (MR) study to analyze the causal relationship between TIA and CAD using data from the FinnGen genome-wide association study. Analysis was performed using the inverse-variance weighted (IVW) method. The robustness of the results was evaluated using MR-Egger regression, the weighted median, MR pleiotropy residual sum, and outlier (MR-PRESSO) and multivariable MR analysis.ResultsResults from IVW random-effect model showed that TIA was associated with an increased risk of coronary artery atherosclerosis (OR 1.17, 95% CI 1.06–1.28, P = 0.002), ischemic heart disease (OR 1.15, 95% CI 1.04–1.27, P = 0.007), and myocardial infarction (OR1.15, 95% CI 1.02–1.29, P = 0.025). In addition, heterogeneity and horizontal pleiotropy were observed in the ischemic heart disease results, while the sensitivity analysis revealed no evidence of horizontal pleiotropy in other outcomes.ConclusionsThis MR study demonstrated a potential causal relationship between TIA and CAD. Further research should be conducted to investigate the mechanism underlying the association. |
| first_indexed | 2024-03-12T14:05:04Z |
| format | Article |
| id | doaj.art-b6ad0fd136124707b8dd65ec8388fdf3 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-12T14:05:04Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b6ad0fd136124707b8dd65ec8388fdf32023-08-21T15:39:47ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-08-011010.3389/fcvm.2023.11926641192664Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysisXiaoyi Qi0Xiaoyi Qi1Shijia Wang2Liangxian Qiu3Xiongbiao Chen4Qianwen Huang5Kunfu Ouyang6Yanjun Chen7Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, ChinaMedical College, Shantou University, Shantou, ChinaDepartments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, ChinaBackgroundAlthough observational studies have shown that patients who experienced transient ischemic attacks (TIAs) had a higher risk of coronary artery disease (CAD), the causal relationship is ambiguous.MethodsWe conducted a two-sample Mendelian randomization (MR) study to analyze the causal relationship between TIA and CAD using data from the FinnGen genome-wide association study. Analysis was performed using the inverse-variance weighted (IVW) method. The robustness of the results was evaluated using MR-Egger regression, the weighted median, MR pleiotropy residual sum, and outlier (MR-PRESSO) and multivariable MR analysis.ResultsResults from IVW random-effect model showed that TIA was associated with an increased risk of coronary artery atherosclerosis (OR 1.17, 95% CI 1.06–1.28, P = 0.002), ischemic heart disease (OR 1.15, 95% CI 1.04–1.27, P = 0.007), and myocardial infarction (OR1.15, 95% CI 1.02–1.29, P = 0.025). In addition, heterogeneity and horizontal pleiotropy were observed in the ischemic heart disease results, while the sensitivity analysis revealed no evidence of horizontal pleiotropy in other outcomes.ConclusionsThis MR study demonstrated a potential causal relationship between TIA and CAD. Further research should be conducted to investigate the mechanism underlying the association.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1192664/fullcoronary artery diseasetransient ischemic attackMendelian randomizationcausal relationshipGWAS—genome-wide association study |
| spellingShingle | Xiaoyi Qi Xiaoyi Qi Shijia Wang Liangxian Qiu Xiongbiao Chen Qianwen Huang Kunfu Ouyang Yanjun Chen Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis Frontiers in Cardiovascular Medicine coronary artery disease transient ischemic attack Mendelian randomization causal relationship GWAS—genome-wide association study |
| title | Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis |
| title_full | Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis |
| title_fullStr | Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis |
| title_full_unstemmed | Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis |
| title_short | Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis |
| title_sort | transient ischemic attack and coronary artery disease a two sample mendelian randomization analysis |
| topic | coronary artery disease transient ischemic attack Mendelian randomization causal relationship GWAS—genome-wide association study |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1192664/full |
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