Regulation of neuronal survival by DNA methyltransferases
The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system. Subordinate to genetic networks epigenetic mechanisms like DNA methylat...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=11;spage=1768;epage=1775;aulast=Symmank |
| _version_ | 1818326880419315712 |
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| author | Judit Symmank Geraldine Zimmer |
| author_facet | Judit Symmank Geraldine Zimmer |
| author_sort | Judit Symmank |
| collection | DOAJ |
| description | The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system. Subordinate to genetic networks epigenetic mechanisms like DNA methylation and histone modifications are involved in the regulation of neuronal development, function and aging. DNA methylation by DNA methyltransferases (DNMTs), mostly correlated with gene silencing, is a dynamic and reversible process. In addition to their canonical actions performing cytosine methylation, DNMTs influence gene expression by interactions with histone modifying enzymes or complexes increasing the complexity of epigenetic transcriptional networks. DNMTs are expressed in neuronal progenitors, post-mitotic as well as adult neurons. In this review, we discuss the role and mode of actions of DNMTs including downstream networks in the regulation of neuronal survival in the developing and aging nervous system and its relevance for associated disorders. |
| first_indexed | 2024-12-13T12:07:24Z |
| format | Article |
| id | doaj.art-b6af135f3547466b81f3565154517ea2 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-13T12:07:24Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-b6af135f3547466b81f3565154517ea22022-12-21T23:46:55ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-0112111768177510.4103/1673-5374.219027Regulation of neuronal survival by DNA methyltransferasesJudit SymmankGeraldine ZimmerThe limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system. Subordinate to genetic networks epigenetic mechanisms like DNA methylation and histone modifications are involved in the regulation of neuronal development, function and aging. DNA methylation by DNA methyltransferases (DNMTs), mostly correlated with gene silencing, is a dynamic and reversible process. In addition to their canonical actions performing cytosine methylation, DNMTs influence gene expression by interactions with histone modifying enzymes or complexes increasing the complexity of epigenetic transcriptional networks. DNMTs are expressed in neuronal progenitors, post-mitotic as well as adult neurons. In this review, we discuss the role and mode of actions of DNMTs including downstream networks in the regulation of neuronal survival in the developing and aging nervous system and its relevance for associated disorders.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=11;spage=1768;epage=1775;aulast=SymmankDNA methyltransferase 1; cortical interneurons; PAK6; neuronal aging; neuropsychiatric diseases; neurodevelopment; neuronal death |
| spellingShingle | Judit Symmank Geraldine Zimmer Regulation of neuronal survival by DNA methyltransferases Neural Regeneration Research DNA methyltransferase 1; cortical interneurons; PAK6; neuronal aging; neuropsychiatric diseases; neurodevelopment; neuronal death |
| title | Regulation of neuronal survival by DNA methyltransferases |
| title_full | Regulation of neuronal survival by DNA methyltransferases |
| title_fullStr | Regulation of neuronal survival by DNA methyltransferases |
| title_full_unstemmed | Regulation of neuronal survival by DNA methyltransferases |
| title_short | Regulation of neuronal survival by DNA methyltransferases |
| title_sort | regulation of neuronal survival by dna methyltransferases |
| topic | DNA methyltransferase 1; cortical interneurons; PAK6; neuronal aging; neuropsychiatric diseases; neurodevelopment; neuronal death |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=11;spage=1768;epage=1775;aulast=Symmank |
| work_keys_str_mv | AT juditsymmank regulationofneuronalsurvivalbydnamethyltransferases AT geraldinezimmer regulationofneuronalsurvivalbydnamethyltransferases |