Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.

Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.

BACKGROUND:Most studies investigating the neurobiology of depression and suicide have focused on the serotonergic system. While it seems clear that serotonergic alterations play a role in the pathogenesis of these major public health problems, dysfunction in additional neurotransmitter systems and o...

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Main Authors: Adolfo Sequeira, Firoza Mamdani, Carl Ernst, Marquis P Vawter, William E Bunney, Veronique Lebel, Sonia Rehal, Tim Klempan, Alain Gratton, Chawki Benkelfat, Guy A Rouleau, Naguib Mechawar, Gustavo Turecki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2719799?pdf=render

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