Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma
Abstract Objective Glaucoma is a chronic neurological disease that is associated with high intraocular pressure (IOP), causes gradual damage to retinal ganglion cells, and often culminates in vision loss. Recent research suggests that glaucoma is a complex multifactorial disease in which multiple in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-022-06210-0 |
| _version_ | 1811189483413962752 |
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| author | Jyoti Kant Choudhari Martin Eberhardt Tanushree Chatterjee Bettina Hohberger Julio Vera |
| author_facet | Jyoti Kant Choudhari Martin Eberhardt Tanushree Chatterjee Bettina Hohberger Julio Vera |
| author_sort | Jyoti Kant Choudhari |
| collection | DOAJ |
| description | Abstract Objective Glaucoma is a chronic neurological disease that is associated with high intraocular pressure (IOP), causes gradual damage to retinal ganglion cells, and often culminates in vision loss. Recent research suggests that glaucoma is a complex multifactorial disease in which multiple interlinked genes and pathways play a role during onset and development. Also, differential availability of trace elements seems to play a role in glaucoma pathophysiology, although their mechanism of action is unknown. The aim of this work is to disseminate a web-based repository on interactions between trace elements and protein-coding genes linked to glaucoma pathophysiology. Results In this study, we present Glaucoma-TrEl, a web database containing information about interactions between trace elements and protein-coding genes that are linked to glaucoma. In the database, we include interactions between 437 unique genes and eight trace elements. Our analysis found a large number of interactions between trace elements and protein-coding genes mutated or linked to the pathophysiology of glaucoma. We associated genes interacting with multiple trace elements to pathways known to play a role in glaucoma. The web-based platform provides an easy-to-use and interactive tool, which serves as an information hub facilitating future research work on trace elements in glaucoma. |
| first_indexed | 2024-04-11T14:35:32Z |
| format | Article |
| id | doaj.art-b6b02dc5523b43d09fa2267dbae2f654 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-11T14:35:32Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-b6b02dc5523b43d09fa2267dbae2f6542022-12-22T04:18:20ZengBMCBMC Research Notes1756-05002022-11-011511810.1186/s13104-022-06210-0Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucomaJyoti Kant Choudhari0Martin Eberhardt1Tanushree Chatterjee2Bettina Hohberger3Julio Vera4Raipur Institute of Technology RaipurLaboratory of Systems Tumor Immunology, Dept. of Dermatology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-NürnbergRaipur Institute of Technology RaipurAugenklinik, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen- NürnbergLaboratory of Systems Tumor Immunology, Dept. of Dermatology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-NürnbergAbstract Objective Glaucoma is a chronic neurological disease that is associated with high intraocular pressure (IOP), causes gradual damage to retinal ganglion cells, and often culminates in vision loss. Recent research suggests that glaucoma is a complex multifactorial disease in which multiple interlinked genes and pathways play a role during onset and development. Also, differential availability of trace elements seems to play a role in glaucoma pathophysiology, although their mechanism of action is unknown. The aim of this work is to disseminate a web-based repository on interactions between trace elements and protein-coding genes linked to glaucoma pathophysiology. Results In this study, we present Glaucoma-TrEl, a web database containing information about interactions between trace elements and protein-coding genes that are linked to glaucoma. In the database, we include interactions between 437 unique genes and eight trace elements. Our analysis found a large number of interactions between trace elements and protein-coding genes mutated or linked to the pathophysiology of glaucoma. We associated genes interacting with multiple trace elements to pathways known to play a role in glaucoma. The web-based platform provides an easy-to-use and interactive tool, which serves as an information hub facilitating future research work on trace elements in glaucoma.https://doi.org/10.1186/s13104-022-06210-0Oxidative stressglaucomaOptic nerveIntraocular pressureProtein-trace element interactions |
| spellingShingle | Jyoti Kant Choudhari Martin Eberhardt Tanushree Chatterjee Bettina Hohberger Julio Vera Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma BMC Research Notes Oxidative stress glaucoma Optic nerve Intraocular pressure Protein-trace element interactions |
| title | Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma |
| title_full | Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma |
| title_fullStr | Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma |
| title_full_unstemmed | Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma |
| title_short | Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma |
| title_sort | glaucoma trel a web based interactive database to build evidence based hypotheses on the role of trace elements in glaucoma |
| topic | Oxidative stress glaucoma Optic nerve Intraocular pressure Protein-trace element interactions |
| url | https://doi.org/10.1186/s13104-022-06210-0 |
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