Adjuvantation of Pulmonary-Administered Influenza Vaccine with GPI-0100 Primarily Stimulates Antibody Production and Memory B Cell Proliferation

Adjuvantation of Pulmonary-Administered Influenza Vaccine with GPI-0100 Primarily Stimulates Antibody Production and Memory B Cell Proliferation

Adjuvants are key components in vaccines, they help in reducing the required antigen dose but also modulate the phenotype of the induced immune response. We previously showed that GPI-0100, a saponin-derived adjuvant, enhances antigen-specific mucosal and systemic antibody responses to influenza sub...

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Bibliographic Details
Main Authors: Harshad P. Patil, José Herrera Rodriguez, Jacqueline de Vries-Idema, Tjarko Meijerhof, Henderik W. Frijlink, Wouter L. J. Hinrichs, Anke Huckriede
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Vaccines
Subjects:
influenza
pulmonary immunization
adjuvant
immune mechanisms
Online Access:https://www.mdpi.com/2076-393X/5/3/19

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