Heterotypic Tumor Spheroids in Agitation-Based Cultures: A Scaffold-Free Cell Model That Sustains Long-Term Survival of Endothelial Cells

Heterotypic Tumor Spheroids in Agitation-Based Cultures: A Scaffold-Free Cell Model That Sustains Long-Term Survival of Endothelial Cells

Endothelial cells (ECs) are an important component of the tumor microenvironment, playing key roles in tumor development and progression that span from angiogenesis to immune regulation and drug resistance. Heterotypic tumor spheroids are one of the most widely used in vitro tumor microenvironment m...

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Bibliographic Details
Main Authors: Teresa Franchi-Mendes, Nuno Lopes, Catarina Brito
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
3D models
spheroids
endothelial cells
fibroblasts
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.649949/full

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