Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review.
Accumulating evidence has implicated an involvement of the gut-brain axis in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), however with highly diverse results. This systematic review aims to describe and evaluate studies investigating the gut microbiota composit...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-09-01
|
| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19490976.2020.1748258 |
| _version_ | 1818663590970785792 |
|---|---|
| author | Caspar Bundgaard-Nielsen Julie Knudsen Peter D. C. Leutscher Marlene B. Lauritsen Mette Nyegaard Søren Hagstrøm Suzette Sørensen |
| author_facet | Caspar Bundgaard-Nielsen Julie Knudsen Peter D. C. Leutscher Marlene B. Lauritsen Mette Nyegaard Søren Hagstrøm Suzette Sørensen |
| author_sort | Caspar Bundgaard-Nielsen |
| collection | DOAJ |
| description | Accumulating evidence has implicated an involvement of the gut-brain axis in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), however with highly diverse results. This systematic review aims to describe and evaluate studies investigating the gut microbiota composition in individuals with ASD or ADHD and to evaluate if variations in gut microbiota are associated with these disorders. Twenty-four articles were identified in a systematic literature search of PubMed and Embase up to July 22, 2019. They consisted of 20 studies investigating ASD and four studies investigating ADHD. For ASD, several studies agreed on an overall difference in β-diversity, although no consistent bacterial variation between all studies was reported. For ADHD, the results were more diverse, with no clear differences observed. Several common characteristics in gut microbiota function were identified for ASD compared to controls. In contrast, highly heterogeneous results were reported for ADHD, and thus the association between gut microbiota composition and ADHD remains unclear. For both disorders, methodological differences hampered the comparison of studies. |
| first_indexed | 2024-12-17T05:19:16Z |
| format | Article |
| id | doaj.art-b6b6a0072c9146679e8f57e55145364a |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-12-17T05:19:16Z |
| publishDate | 2020-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-b6b6a0072c9146679e8f57e55145364a2022-12-21T22:02:02ZengTaylor & Francis GroupGut Microbes1949-09761949-09842020-09-011151172118710.1080/19490976.2020.17482581748258Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review.Caspar Bundgaard-Nielsen0Julie Knudsen1Peter D. C. Leutscher2Marlene B. Lauritsen3Mette Nyegaard4Søren Hagstrøm5Suzette Sørensen6Centre for Clinical Research, North Denmark Regional HospitalCentre for Clinical Research, North Denmark Regional HospitalCentre for Clinical Research, North Denmark Regional HospitalAalborg University HospitalAarhus UniversityCentre for Clinical Research, North Denmark Regional HospitalCentre for Clinical Research, North Denmark Regional HospitalAccumulating evidence has implicated an involvement of the gut-brain axis in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), however with highly diverse results. This systematic review aims to describe and evaluate studies investigating the gut microbiota composition in individuals with ASD or ADHD and to evaluate if variations in gut microbiota are associated with these disorders. Twenty-four articles were identified in a systematic literature search of PubMed and Embase up to July 22, 2019. They consisted of 20 studies investigating ASD and four studies investigating ADHD. For ASD, several studies agreed on an overall difference in β-diversity, although no consistent bacterial variation between all studies was reported. For ADHD, the results were more diverse, with no clear differences observed. Several common characteristics in gut microbiota function were identified for ASD compared to controls. In contrast, highly heterogeneous results were reported for ADHD, and thus the association between gut microbiota composition and ADHD remains unclear. For both disorders, methodological differences hampered the comparison of studies.http://dx.doi.org/10.1080/19490976.2020.1748258autism spectrum disorderattention-deficit hyperactivity disorderneurodevelopmental disordersmicrobiotamicrobiomesystematic reviewgut-brain axis |
| spellingShingle | Caspar Bundgaard-Nielsen Julie Knudsen Peter D. C. Leutscher Marlene B. Lauritsen Mette Nyegaard Søren Hagstrøm Suzette Sørensen Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review. Gut Microbes autism spectrum disorder attention-deficit hyperactivity disorder neurodevelopmental disorders microbiota microbiome systematic review gut-brain axis |
| title | Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review. |
| title_full | Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review. |
| title_fullStr | Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review. |
| title_full_unstemmed | Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review. |
| title_short | Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review. |
| title_sort | gut microbiota profiles of autism spectrum disorder and attention deficit hyperactivity disorder a systematic literature review |
| topic | autism spectrum disorder attention-deficit hyperactivity disorder neurodevelopmental disorders microbiota microbiome systematic review gut-brain axis |
| url | http://dx.doi.org/10.1080/19490976.2020.1748258 |
| work_keys_str_mv | AT casparbundgaardnielsen gutmicrobiotaprofilesofautismspectrumdisorderandattentiondeficithyperactivitydisorderasystematicliteraturereview AT julieknudsen gutmicrobiotaprofilesofautismspectrumdisorderandattentiondeficithyperactivitydisorderasystematicliteraturereview AT peterdcleutscher gutmicrobiotaprofilesofautismspectrumdisorderandattentiondeficithyperactivitydisorderasystematicliteraturereview AT marleneblauritsen gutmicrobiotaprofilesofautismspectrumdisorderandattentiondeficithyperactivitydisorderasystematicliteraturereview AT mettenyegaard gutmicrobiotaprofilesofautismspectrumdisorderandattentiondeficithyperactivitydisorderasystematicliteraturereview AT sørenhagstrøm gutmicrobiotaprofilesofautismspectrumdisorderandattentiondeficithyperactivitydisorderasystematicliteraturereview AT suzettesørensen gutmicrobiotaprofilesofautismspectrumdisorderandattentiondeficithyperactivitydisorderasystematicliteraturereview |