Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis
Abstract Background Although imbalanced intestinal flora contributes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD), conflicting results have been obtained for patient-derived microbiome composition analyses. A meta-analysis was performed to summarize the characteristics of intestin...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-021-01440-w |
| _version_ | 1818379451898003456 |
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| author | Fuxi Li Junzhao Ye Congxiang Shao Bihui Zhong |
| author_facet | Fuxi Li Junzhao Ye Congxiang Shao Bihui Zhong |
| author_sort | Fuxi Li |
| collection | DOAJ |
| description | Abstract Background Although imbalanced intestinal flora contributes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD), conflicting results have been obtained for patient-derived microbiome composition analyses. A meta-analysis was performed to summarize the characteristics of intestinal microbiota at the species level in NAFLD patients. Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement, a completed search (last update: December 30, 2020) of databases was performed to identify eligible case-control studies detecting gut microbiota in NAFLD patients. The meta-analysis results are presented as the standard mean difference (SMD) and 95% confidence interval (CI). Bias controls were evaluated with the Newcastle-Ottawa Scale (NOS), funnel plot analysis, and Egger’s and Begg’s tests. Results Fifteen studies (NOS score range: 6–8) that detected the gut microbiota in the stools of 1265 individuals (577 NAFLD patients and 688 controls) were included. It was found that Escherichia, Prevotella and Streptococcus (SMD = 1.55 [95% CI: 0.57, 2.54], 1.89 [95% CI: 0.02, 3.76] and 1.33 [95% CI: 0.62, 2.05], respectively) exhibited increased abundance while Coprococcus, Faecalibacterium and Ruminococcus (SMD = − 1.75 [95% CI: − 3.13, − 0.37], − 9.84 [95% CI: − 13.21, − 6.47] and − 1.84 [95% CI, − 2.41, − 1.27], respectively) exhibited decreased abundance in the NAFLD patients compared with healthy controls. No differences in the abundance of Bacteroides, Bifidobacterium, Blautia, Clostridium, Dorea, Lactobacillus, Parabacteroides or Roseburia were confirmed between the NAFLD patients and healthy controls. Conclusions This meta-analysis revealed that changes in the abundance of Escherichia, Prevotella, Streptococcus, Coprococcus, Faecalibacterium and Ruminococcus were the universal intestinal bacterial signature of NAFLD. |
| first_indexed | 2024-12-14T02:03:00Z |
| format | Article |
| id | doaj.art-b6b6ea62d0da49868cf977d702322127 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-14T02:03:00Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-b6b6ea62d0da49868cf977d7023221272022-12-21T23:20:57ZengBMCLipids in Health and Disease1476-511X2021-02-0120111210.1186/s12944-021-01440-wCompositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysisFuxi Li0Junzhao Ye1Congxiang Shao2Bihui Zhong3Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityAbstract Background Although imbalanced intestinal flora contributes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD), conflicting results have been obtained for patient-derived microbiome composition analyses. A meta-analysis was performed to summarize the characteristics of intestinal microbiota at the species level in NAFLD patients. Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement, a completed search (last update: December 30, 2020) of databases was performed to identify eligible case-control studies detecting gut microbiota in NAFLD patients. The meta-analysis results are presented as the standard mean difference (SMD) and 95% confidence interval (CI). Bias controls were evaluated with the Newcastle-Ottawa Scale (NOS), funnel plot analysis, and Egger’s and Begg’s tests. Results Fifteen studies (NOS score range: 6–8) that detected the gut microbiota in the stools of 1265 individuals (577 NAFLD patients and 688 controls) were included. It was found that Escherichia, Prevotella and Streptococcus (SMD = 1.55 [95% CI: 0.57, 2.54], 1.89 [95% CI: 0.02, 3.76] and 1.33 [95% CI: 0.62, 2.05], respectively) exhibited increased abundance while Coprococcus, Faecalibacterium and Ruminococcus (SMD = − 1.75 [95% CI: − 3.13, − 0.37], − 9.84 [95% CI: − 13.21, − 6.47] and − 1.84 [95% CI, − 2.41, − 1.27], respectively) exhibited decreased abundance in the NAFLD patients compared with healthy controls. No differences in the abundance of Bacteroides, Bifidobacterium, Blautia, Clostridium, Dorea, Lactobacillus, Parabacteroides or Roseburia were confirmed between the NAFLD patients and healthy controls. Conclusions This meta-analysis revealed that changes in the abundance of Escherichia, Prevotella, Streptococcus, Coprococcus, Faecalibacterium and Ruminococcus were the universal intestinal bacterial signature of NAFLD.https://doi.org/10.1186/s12944-021-01440-wNonalcoholic fatty liver diseaseNonalcoholic steatohepatitisGutMicrobiomeBacterial compositionMicrobiota |
| spellingShingle | Fuxi Li Junzhao Ye Congxiang Shao Bihui Zhong Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis Lipids in Health and Disease Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Gut Microbiome Bacterial composition Microbiota |
| title | Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis |
| title_full | Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis |
| title_fullStr | Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis |
| title_full_unstemmed | Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis |
| title_short | Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis |
| title_sort | compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients a systematic review and meta analysis |
| topic | Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Gut Microbiome Bacterial composition Microbiota |
| url | https://doi.org/10.1186/s12944-021-01440-w |
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