EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR
Changes in the lipid profile in pregnant women, with and without obesity, have been studied depending on the angiotensin-converting enzyme (ACE) gene I/ D polymorphism and the 4G5G polymorphism of the plasminogen activator inhibitor type I (PAI-1). The combination of the D-allele of the ACE gene and...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Balkan Medical Union
2018-06-01
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| Series: | Archives of the Balkan Medical Union |
| Subjects: | |
| Online Access: | http://umbalk.org/wp-content/uploads/2018/06/05.Examination-of-the-lipid-profile-in-pregnant-obese-women.pdf |
| Summary: | Changes in the lipid profile in pregnant women, with and without obesity, have been studied depending on the angiotensin-converting enzyme (ACE) gene I/ D polymorphism and the 4G5G polymorphism of the plasminogen activator inhibitor type I (PAI-1). The combination of the D-allele of the ACE gene and the 5G allele of the PAI-1 gene is a risk factor of increasing total cholesterol in pregnant women, regardless of the obesity class, and of increasing triglycerides in pregnant women without obesity. The presence of the D-allele of the ACE gene in the haplotype, regardless of the combinations of the genotypes of the PAI-1 gene, is a risk factor of increasing triglycerides in pregnant women with obesity. |
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| ISSN: | 1584-9244 2558-815X |