EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR
Changes in the lipid profile in pregnant women, with and without obesity, have been studied depending on the angiotensin-converting enzyme (ACE) gene I/ D polymorphism and the 4G5G polymorphism of the plasminogen activator inhibitor type I (PAI-1). The combination of the D-allele of the ACE gene and...
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| Format: | Article |
| Language: | English |
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Balkan Medical Union
2018-06-01
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| Series: | Archives of the Balkan Medical Union |
| Subjects: | |
| Online Access: | http://umbalk.org/wp-content/uploads/2018/06/05.Examination-of-the-lipid-profile-in-pregnant-obese-women.pdf |
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| author | Tetiana S. BULYK Vasyl Y. RYNZHUK Marina D. GRESKO Larisa V. RYNZHUK Larisa P. SYDORCHUK Vitaliy V. MAKSIMYUK Yuriy O. MALYSHEVSKYI Mariana I. KRYVCHANSKA Violeta G. KHOMENKO Kateryna V. VLASOVA Tetiana A. GLUSHCHENKO Victor M. BATIG |
| author_facet | Tetiana S. BULYK Vasyl Y. RYNZHUK Marina D. GRESKO Larisa V. RYNZHUK Larisa P. SYDORCHUK Vitaliy V. MAKSIMYUK Yuriy O. MALYSHEVSKYI Mariana I. KRYVCHANSKA Violeta G. KHOMENKO Kateryna V. VLASOVA Tetiana A. GLUSHCHENKO Victor M. BATIG |
| author_sort | Tetiana S. BULYK |
| collection | DOAJ |
| description | Changes in the lipid profile in pregnant women, with and without obesity, have been studied depending on the angiotensin-converting enzyme (ACE) gene I/ D polymorphism and the 4G5G polymorphism of the plasminogen activator inhibitor type I (PAI-1). The combination of the D-allele of the ACE gene and the 5G allele of the PAI-1 gene is a risk factor of increasing total cholesterol in pregnant women, regardless of the obesity class, and of increasing triglycerides in pregnant women without obesity. The presence of the D-allele of the ACE gene in the haplotype, regardless of the combinations of the genotypes of the PAI-1 gene, is a risk factor of increasing triglycerides in pregnant women with obesity. |
| first_indexed | 2024-12-11T10:10:30Z |
| format | Article |
| id | doaj.art-b6b776e650cf42c281eced49d5f041ed |
| institution | Directory Open Access Journal |
| issn | 1584-9244 2558-815X |
| language | English |
| last_indexed | 2024-12-11T10:10:30Z |
| publishDate | 2018-06-01 |
| publisher | Balkan Medical Union |
| record_format | Article |
| series | Archives of the Balkan Medical Union |
| spelling | doaj.art-b6b776e650cf42c281eced49d5f041ed2022-12-22T01:11:46ZengBalkan Medical UnionArchives of the Balkan Medical Union1584-92442558-815X2018-06-0153220520910.31688/ABMU.2018.53.2.05EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITORTetiana S. BULYK0Vasyl Y. RYNZHUK1Marina D. GRESKO2Larisa V. RYNZHUK3Larisa P. SYDORCHUK4Vitaliy V. MAKSIMYUK5Yuriy O. MALYSHEVSKYI6Mariana I. KRYVCHANSKA7Violeta G. KHOMENKO8Kateryna V. VLASOVA9Tetiana A. GLUSHCHENKO10Victor M. BATIG11Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Family Medicine, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Surgery No 1, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Oncology and Radiology, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Medical Biology and Genetics, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Medical Biology and Genetics, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Medical Biology and Genetics, Bukovinian State Medical University, Chernivtsi, UkraineDepartment of Therapeutic Stomatology, BSMU, UkraineDepartment of Therapeutic Stomatology, BSMU, UkraineChanges in the lipid profile in pregnant women, with and without obesity, have been studied depending on the angiotensin-converting enzyme (ACE) gene I/ D polymorphism and the 4G5G polymorphism of the plasminogen activator inhibitor type I (PAI-1). The combination of the D-allele of the ACE gene and the 5G allele of the PAI-1 gene is a risk factor of increasing total cholesterol in pregnant women, regardless of the obesity class, and of increasing triglycerides in pregnant women without obesity. The presence of the D-allele of the ACE gene in the haplotype, regardless of the combinations of the genotypes of the PAI-1 gene, is a risk factor of increasing triglycerides in pregnant women with obesity.http://umbalk.org/wp-content/uploads/2018/06/05.Examination-of-the-lipid-profile-in-pregnant-obese-women.pdfpregnancyobesitylipidsACE gene polymorphismPAI-1gene polymorphism |
| spellingShingle | Tetiana S. BULYK Vasyl Y. RYNZHUK Marina D. GRESKO Larisa V. RYNZHUK Larisa P. SYDORCHUK Vitaliy V. MAKSIMYUK Yuriy O. MALYSHEVSKYI Mariana I. KRYVCHANSKA Violeta G. KHOMENKO Kateryna V. VLASOVA Tetiana A. GLUSHCHENKO Victor M. BATIG EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR Archives of the Balkan Medical Union pregnancy obesity lipids ACE gene polymorphism PAI-1gene polymorphism |
| title | EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR |
| title_full | EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR |
| title_fullStr | EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR |
| title_full_unstemmed | EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR |
| title_short | EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR |
| title_sort | examination of the lipid profile in pregnant obese women considering the allele status of the genes of angiotensin converting enzyme ace i d and plasminogen 1 pa 1 4g 5g activator inhibitor |
| topic | pregnancy obesity lipids ACE gene polymorphism PAI-1gene polymorphism |
| url | http://umbalk.org/wp-content/uploads/2018/06/05.Examination-of-the-lipid-profile-in-pregnant-obese-women.pdf |
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