1,1,1,3,3,3-Hexafluoro-2-Propanol-Promoted Friedel–Crafts Reaction: Metal-Free Synthesis of C3-Difluoromethyl Carbinol-Containing Imidazo[1,2-<i>a</i>]pyridines at Room Temperature

1,1,1,3,3,3-Hexafluoro-2-Propanol-Promoted Friedel–Crafts Reaction: Metal-Free Synthesis of C3-Difluoromethyl Carbinol-Containing Imidazo[1,2-<i>a</i>]pyridines at Room Temperature

A facile and efficient method has been developed for the synthesis of C3-difluoromethyl carbinol-containing imidazo[1,2-<i>a</i>]pyridines at room temperature via the HFIP-promoted Friedel–Crafts reaction of difluoroacetaldehyde ethyl hemiacetal and imidazo[1,2-<i>a</i>]pyrid...

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Bibliographic Details
Main Authors: Juanjuan Gao, Zhaowen Liu, Xiaohua Guo, Longhui Wu, Zhixi Chen, Kai Yang
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
hydroxydifluoromethylation
Friedel–Crafts reaction
imidazo[1,2-<i>a</i>]pyridine
HFIP
Online Access:https://www.mdpi.com/1420-3049/28/22/7522

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