SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois?
As we enter year 3 of SARS-CoV-2 pandemic, long-term consequences of COVID-19 have become a major public health issue worldwide; however, the molecular and cellular underpinnings of ‘long COVID’ remain very poorly understood. A paradigm has recently emerged that thrombo-inflammatory consequences of...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-07-01
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| Series: | EFORT Open Reviews |
| Subjects: | |
| Online Access: | https://vb.bioscientifica.com/view/journals/vb/4/1/VB-22-0004.xml |
| _version_ | 1811291658776477696 |
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| author | Vladimir Y Bogdanov Vladimir N Khirmanov |
| author_facet | Vladimir Y Bogdanov Vladimir N Khirmanov |
| author_sort | Vladimir Y Bogdanov |
| collection | DOAJ |
| description | As we enter year 3 of SARS-CoV-2 pandemic, long-term consequences of COVID-19 have become a major public health issue worldwide; however, the molecular and cellular underpinnings of ‘long COVID’ remain very poorly understood. A paradigm has recently emerged that thrombo-inflammatory consequences of SARS-CoV-2’s impact on endothelial cells and platelets likely play a significant role in the development of chronic symptomatology associated with COVID-19. In this brief overview, we discuss the recent findings pertaining to the detection of SARS-CoV-2 virions in vascular cell subtypes, the contribution of the coagulation system to the development of ‘long COVID’, and the potential role of stem/progenitor cells in the viral and thrombotic dissemination in this disorder. |
| first_indexed | 2024-04-13T04:32:18Z |
| format | Article |
| id | doaj.art-b6b8be470eaa4e939803b399f12771c0 |
| institution | Directory Open Access Journal |
| issn | 2058-5241 |
| language | English |
| last_indexed | 2024-04-13T04:32:18Z |
| publishDate | 2022-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | EFORT Open Reviews |
| spelling | doaj.art-b6b8be470eaa4e939803b399f12771c02022-12-22T03:02:17ZengBioscientificaEFORT Open Reviews2058-52412022-07-0141R35R43https://doi.org/10.1530/VB-22-0004SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois?Vladimir Y Bogdanov0Vladimir N Khirmanov1Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USADepartment of Cardiovascular Medicine, Nikiforov’s All-Russian Center for Emergency and Radiation Medicine, Saint Petersburg, RussiaAs we enter year 3 of SARS-CoV-2 pandemic, long-term consequences of COVID-19 have become a major public health issue worldwide; however, the molecular and cellular underpinnings of ‘long COVID’ remain very poorly understood. A paradigm has recently emerged that thrombo-inflammatory consequences of SARS-CoV-2’s impact on endothelial cells and platelets likely play a significant role in the development of chronic symptomatology associated with COVID-19. In this brief overview, we discuss the recent findings pertaining to the detection of SARS-CoV-2 virions in vascular cell subtypes, the contribution of the coagulation system to the development of ‘long COVID’, and the potential role of stem/progenitor cells in the viral and thrombotic dissemination in this disorder.https://vb.bioscientifica.com/view/journals/vb/4/1/VB-22-0004.xmlendotheliumplateletsthrombosislong covid |
| spellingShingle | Vladimir Y Bogdanov Vladimir N Khirmanov SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois? EFORT Open Reviews endothelium platelets thrombosis long covid |
| title | SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois? |
| title_full | SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois? |
| title_fullStr | SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois? |
| title_full_unstemmed | SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois? |
| title_short | SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois? |
| title_sort | sars cov 2 platelets and endothelium coexistence in space and time or a pernicious menage a trois |
| topic | endothelium platelets thrombosis long covid |
| url | https://vb.bioscientifica.com/view/journals/vb/4/1/VB-22-0004.xml |
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