Experimental models for nephropathy
Nephropathy is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialised nations. Nephropathy is characterised to varying degrees by nodular glomerulosclerosis, glomerular basement membrane thickness and mesangial expansion, leading to a decline in gl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2008-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320308098343 |
| _version_ | 1797282645668790272 |
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| author | Pitchal Balakumar Vishal Arvind Chakkarwar Vijay Kumar Akash Jain Jayarami Reddy Manjeet Singh |
| author_facet | Pitchal Balakumar Vishal Arvind Chakkarwar Vijay Kumar Akash Jain Jayarami Reddy Manjeet Singh |
| author_sort | Pitchal Balakumar |
| collection | DOAJ |
| description | Nephropathy is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialised nations. Nephropathy is characterised to varying degrees by nodular glomerulosclerosis, glomerular basement membrane thickness and mesangial expansion, leading to a decline in glomerular filtration rate, persistent elevated albuminuria, elevated arterial blood pressure and fluid retention. Hyperglycaemia, hyperlipidaemia and hypertension are considered to be the major risk factors implicated in the progression of nephropathy.Various signalling systems, such as vasoconstrictor peptides, inflammatory mediators, growth factors and adhesion molecules, are involved in the pathogenesis of nephropathy.At present, no promising therapy is available to treat patients with nephropathy due to lack of understanding of signalling culprits involved in the pathogenesis of nephropathy. Animal models are being developed to better understand the disease pathogenesis and develop drugs for nephropathy. In the present review, we have discussed various animal models for nephropathy, which may open vistas for developing new drugs to treat nephropathy. |
| first_indexed | 2024-03-07T17:17:25Z |
| format | Article |
| id | doaj.art-b6b8f45588ca4cdba75aada0bdffd105 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T17:17:25Z |
| publishDate | 2008-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-b6b8f45588ca4cdba75aada0bdffd1052024-03-02T22:03:04ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032008-12-01910.1177/1470320308098343Experimental models for nephropathyPitchal Balakumar Vishal Arvind ChakkarwarVijay KumarAkash JainJayarami ReddyManjeet SinghNephropathy is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialised nations. Nephropathy is characterised to varying degrees by nodular glomerulosclerosis, glomerular basement membrane thickness and mesangial expansion, leading to a decline in glomerular filtration rate, persistent elevated albuminuria, elevated arterial blood pressure and fluid retention. Hyperglycaemia, hyperlipidaemia and hypertension are considered to be the major risk factors implicated in the progression of nephropathy.Various signalling systems, such as vasoconstrictor peptides, inflammatory mediators, growth factors and adhesion molecules, are involved in the pathogenesis of nephropathy.At present, no promising therapy is available to treat patients with nephropathy due to lack of understanding of signalling culprits involved in the pathogenesis of nephropathy. Animal models are being developed to better understand the disease pathogenesis and develop drugs for nephropathy. In the present review, we have discussed various animal models for nephropathy, which may open vistas for developing new drugs to treat nephropathy.https://doi.org/10.1177/1470320308098343 |
| spellingShingle | Pitchal Balakumar Vishal Arvind Chakkarwar Vijay Kumar Akash Jain Jayarami Reddy Manjeet Singh Experimental models for nephropathy Journal of the Renin-Angiotensin-Aldosterone System |
| title | Experimental models for nephropathy |
| title_full | Experimental models for nephropathy |
| title_fullStr | Experimental models for nephropathy |
| title_full_unstemmed | Experimental models for nephropathy |
| title_short | Experimental models for nephropathy |
| title_sort | experimental models for nephropathy |
| url | https://doi.org/10.1177/1470320308098343 |
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