Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
Tumors can overproduce pro-angiogenic ligands overcoming currently approved anti-angiogenic therapies and hindering their success. Here, the authors show that targeting phosphoinositide recycling during tumor angiogenesis harnesses the tumor’s own production of angiogenic ligands to deplete adjacent...
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Bibliographic Details
| Main Authors: |
Amber N. Stratman,
Olivia M. Farrelly,
Constantinos M. Mikelis,
Mayumi F. Miller,
Zhiyong Wang,
Van N. Pham,
Andrew E. Davis,
Margaret C. Burns,
Sofia A. Pezoa,
Daniel Castranova,
Joseph J. Yano,
Tina M. Kilts,
George E. Davis,
J. Silvio Gutkind,
Brant M. Weinstein |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14956-z
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