From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution
Abstract The simultaneous detection of BCR::ABL1 and JAK2 V617F was rarely reported and their clonal relationship and dynamic clonal shift were not characterized. Here, we described a unique case with the initial presentation as JAK2 V617F+ primary myelofibrosis, followed by the emergence of BCR::AB...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.806 |
| _version_ | 1827342570525556736 |
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| author | Devin Wang Wataru Kamata Fengxi Ye M. James You |
| author_facet | Devin Wang Wataru Kamata Fengxi Ye M. James You |
| author_sort | Devin Wang |
| collection | DOAJ |
| description | Abstract The simultaneous detection of BCR::ABL1 and JAK2 V617F was rarely reported and their clonal relationship and dynamic clonal shift were not characterized. Here, we described a unique case with the initial presentation as JAK2 V617F+ primary myelofibrosis, followed by the emergence of BCR::ABL1+ chronic myeloid leukemia. The patient then developed BCR::ABL1+ B‐lymphoblastic leukemia. Treatment for B‐lymphoblastic leukemia prompted a regression to the state of primary myelofibrosis. In light of these observations, we proposed a clonal evolution model for this case. |
| first_indexed | 2024-03-07T22:09:28Z |
| format | Article |
| id | doaj.art-b6bbe0ad9a914f62912730aeb05d1be9 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-07T22:09:28Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-b6bbe0ad9a914f62912730aeb05d1be92024-02-23T16:50:43ZengWileyeJHaem2688-61462024-02-015115716110.1002/jha2.806From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolutionDevin Wang0Wataru Kamata1Fengxi Ye2M. James You3Department of HematopathologyThe University of Texas MD Anderson Cancer CenterHoustonTexasUSADepartment of HematopathologyThe University of Texas MD Anderson Cancer CenterHoustonTexasUSADepartment of HematopathologyThe University of Texas MD Anderson Cancer CenterHoustonTexasUSADepartment of HematopathologyThe University of Texas MD Anderson Cancer CenterHoustonTexasUSAAbstract The simultaneous detection of BCR::ABL1 and JAK2 V617F was rarely reported and their clonal relationship and dynamic clonal shift were not characterized. Here, we described a unique case with the initial presentation as JAK2 V617F+ primary myelofibrosis, followed by the emergence of BCR::ABL1+ chronic myeloid leukemia. The patient then developed BCR::ABL1+ B‐lymphoblastic leukemia. Treatment for B‐lymphoblastic leukemia prompted a regression to the state of primary myelofibrosis. In light of these observations, we proposed a clonal evolution model for this case.https://doi.org/10.1002/jha2.806BCR::ABL1 + B‐ALLclonal evolutionCMLJAK2 V617FPMF |
| spellingShingle | Devin Wang Wataru Kamata Fengxi Ye M. James You From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution eJHaem BCR::ABL1 + B‐ALL clonal evolution CML JAK2 V617F PMF |
| title | From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution |
| title_full | From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution |
| title_fullStr | From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution |
| title_full_unstemmed | From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution |
| title_short | From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution |
| title_sort | from primary myelofibrosis to chronic myeloid leukemia bcr abl1 b lymphoblastic leukemia and back to primary myelofibrosis an illustration of dynamic clonal evolution |
| topic | BCR::ABL1 + B‐ALL clonal evolution CML JAK2 V617F PMF |
| url | https://doi.org/10.1002/jha2.806 |
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