Disruption of FLNB leads to skeletal malformation by interfering with skeletal segmentation through the HOX gene

Disruption of FLNB leads to skeletal malformation by interfering with skeletal segmentation through the HOX gene

Filamin B (FLNB) plays an important role in skeletal development. Mutations in FLNB can lead to skeletal malformation such as an abnormal number of ossification centers, indicating that the skeletal segmentation in the embryonic period may be interfered with. We established a mouse model with the pa...

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Bibliographic Details
Main Authors: Qiming Xu, Lijia Cui, Yude Lin, Leigh-Anne Cui, Weibo Xia
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Bone Reports
Subjects:
Filamin B
HOX
Skeletal segmentation
CRISPR-Cas9
In situ hybridization of embryo
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187224000135

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