COVID-19 in newborns and in children: the state of the art

Novel COronaVIrus Disease 2019 (COVID-19) is an emerging disease of public health concern because it is caused by a newly identified pathogen, against which humans have no pre-existing immunity. Since its outbreak, a growing number of studies have examined COVID-19 in adults, but the data on its epi...

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Main Authors: Valentina Paraluppi, Maria Cristina Pintus, Vassilios Fanos, Maria Antonietta Marcialis
Format: Article
Language:English
Published: Hygeia Press di Corridori Marinella 2020-03-01
Series:Journal of Pediatric and Neonatal Individualized Medicine
Subjects:
Online Access:https://www.jpnim.com/index.php/jpnim/article/view/912
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author Valentina Paraluppi
Maria Cristina Pintus
Vassilios Fanos
Maria Antonietta Marcialis
author_facet Valentina Paraluppi
Maria Cristina Pintus
Vassilios Fanos
Maria Antonietta Marcialis
author_sort Valentina Paraluppi
collection DOAJ
description Novel COronaVIrus Disease 2019 (COVID-19) is an emerging disease of public health concern because it is caused by a newly identified pathogen, against which humans have no pre-existing immunity. Since its outbreak, a growing number of studies have examined COVID-19 in adults, but the data on its epidemiological and clinical characteristics in newborns and in children are few and patchy. Children appear to develop moderate-mild or silent forms of the disease; to our knowledge, only two cases of death (a 14-year-old and a 16-year-old teenagers) have been reported. Arguably, the number of pediatric cases may be underestimated, since presumably cases with mild or no symptoms are not brought to the doctor’s attention. We have selected the most interesting and significant papers (including some pre-publication or ahead-of-print papers). The key factors in the pathophysiology of COVID-19, available data on pregnancy, the neonatal period, and later are discussed. A review of pediatric cases is available and 3 practical algorithms help the reader in clinical choices. Finally, diagnostic criteria and treatment are presented.
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spelling doaj.art-b6be923916094e7cbc5769536acf3c492022-12-21T23:42:30ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922020-03-0191e090138e09013810.7363/090138771COVID-19 in newborns and in children: the state of the artValentina Paraluppi0Maria Cristina Pintus1Vassilios Fanos2Maria Antonietta Marcialis3School of Pediatrics, University of Cagliari, Cagliari, ItalyNeonatal Intensive Care Unit, Azienda Ospedalera Universitaria, Cagliari, ItalyNeonatal Intensive Care Unit, Azienda Ospedalera Universitaria and University of Cagliari, Cagliari, ItalyNeonatal Intensive Care Unit, Azienda Ospedalera Universitaria, Cagliari, ItalyNovel COronaVIrus Disease 2019 (COVID-19) is an emerging disease of public health concern because it is caused by a newly identified pathogen, against which humans have no pre-existing immunity. Since its outbreak, a growing number of studies have examined COVID-19 in adults, but the data on its epidemiological and clinical characteristics in newborns and in children are few and patchy. Children appear to develop moderate-mild or silent forms of the disease; to our knowledge, only two cases of death (a 14-year-old and a 16-year-old teenagers) have been reported. Arguably, the number of pediatric cases may be underestimated, since presumably cases with mild or no symptoms are not brought to the doctor’s attention. We have selected the most interesting and significant papers (including some pre-publication or ahead-of-print papers). The key factors in the pathophysiology of COVID-19, available data on pregnancy, the neonatal period, and later are discussed. A review of pediatric cases is available and 3 practical algorithms help the reader in clinical choices. Finally, diagnostic criteria and treatment are presented.https://www.jpnim.com/index.php/jpnim/article/view/912covid-19sars-cov-2coronaviruspregnancynewborninfantchildreview
spellingShingle Valentina Paraluppi
Maria Cristina Pintus
Vassilios Fanos
Maria Antonietta Marcialis
COVID-19 in newborns and in children: the state of the art
Journal of Pediatric and Neonatal Individualized Medicine
covid-19
sars-cov-2
coronavirus
pregnancy
newborn
infant
child
review
title COVID-19 in newborns and in children: the state of the art
title_full COVID-19 in newborns and in children: the state of the art
title_fullStr COVID-19 in newborns and in children: the state of the art
title_full_unstemmed COVID-19 in newborns and in children: the state of the art
title_short COVID-19 in newborns and in children: the state of the art
title_sort covid 19 in newborns and in children the state of the art
topic covid-19
sars-cov-2
coronavirus
pregnancy
newborn
infant
child
review
url https://www.jpnim.com/index.php/jpnim/article/view/912
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AT mariacristinapintus covid19innewbornsandinchildrenthestateoftheart
AT vassiliosfanos covid19innewbornsandinchildrenthestateoftheart
AT mariaantoniettamarcialis covid19innewbornsandinchildrenthestateoftheart