North Korean defectors with PTSD and complex PTSD show alterations in default mode network resting-state functional connectivity
Background North Korean defectors (NKDs) have often been exposed to traumatic events. However, there have been few studies of neural alterations in NKDs with post-traumatic stress disorder (PTSD) and complex PTSD (cPTSD). Aims To investigate neural alterations in NKDs with PTSD and cPTSD, with a sp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | BJPsych Open |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472423006361/type/journal_article |
| _version_ | 1797365311917260800 |
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| author | Byung-Hoon Kim Jiwon Baek Ocksim Kim Hokon Kim Minjeong Ko Sang Hui Chu Young-Chul Jung |
| author_facet | Byung-Hoon Kim Jiwon Baek Ocksim Kim Hokon Kim Minjeong Ko Sang Hui Chu Young-Chul Jung |
| author_sort | Byung-Hoon Kim |
| collection | DOAJ |
| description | Background
North Korean defectors (NKDs) have often been exposed to traumatic events. However, there have been few studies of neural alterations in NKDs with post-traumatic stress disorder (PTSD) and complex PTSD (cPTSD).
Aims
To investigate neural alterations in NKDs with PTSD and cPTSD, with a specific focus on alterations in resting-state functional connectivity networks, including the default mode network (DMN).
Method
Resting-state functional connectivity was assessed using brain functional magnetic resonance imaging in three groups of NKDs: without PTSD, with PTSD and with cPTSD. Statistical tests were performed, including region of interest (ROI)-to-ROI and ROI-to-voxel analysis, followed by post hoc correlation analysis.
Results
In the ROI-to-ROI analysis, differences in functional connectivity were found among the components of the DMN, as well as in the thalamus and the basal ganglia. Right hippocampus–left pallidum and right amygdala–left lingual gyrus connectivity differed between groups in the ROI-to-voxel analysis, as did connectivity involving the basal ganglia. The post hoc analysis revealed negative correlations between Coping and Adaptation Processing Scale (CAPS) score and left posterior cingulate cortex–right pallidum connectivity and between CAPS score and right putamen–left angular gyrus connectivity in the control group, which were not observed in other groups.
Conclusions
The results suggest that there are alterations in the functional connectivity of the DMN and the limbic system in NKDs with PTSD and cPTSD, and that these alterations involve the basal ganglia. The lower correlations of CAPS score with right basal ganglia–DMN functional connectivity in patients compared with controls further implies that these connectivities are potential targets for treatment of PTSD and cPTSD.
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| first_indexed | 2024-03-08T16:47:20Z |
| format | Article |
| id | doaj.art-b6c174e43f194bf5b2f03c36a334691e |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-03-08T16:47:20Z |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-b6c174e43f194bf5b2f03c36a334691e2024-01-05T08:48:29ZengCambridge University PressBJPsych Open2056-47242024-01-011010.1192/bjo.2023.636North Korean defectors with PTSD and complex PTSD show alterations in default mode network resting-state functional connectivityByung-Hoon Kim0https://orcid.org/0000-0003-2501-038XJiwon Baek1Ocksim Kim2Hokon Kim3Minjeong Ko4Sang Hui Chu5Young-Chul Jung6https://orcid.org/0000-0002-0578-2510Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea; and Institute of Behavioral Sciences in Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaMo-Im Kim Nursing Research Institute, Yonsei University College of Nursing, Seoul, South KoreaDepartment of Nursing, Yonsei University College of Nursing and Brain Korea 21 FOUR Project, Seoul, South KoreaDepartment of Nursing, Yonsei University College of Nursing, Seoul, South Korea; and Brain Korea 21 FOUR Project, Seoul, South KoreaDepartment of Nursing, Yonsei University College of Nursing, Seoul, South KoreaMo-Im Kim Nursing Research Institute, Yonsei University College of Nursing, Seoul, South Korea; and Department of Nursing, Yonsei University College of Nursing, Seoul, South KoreaDepartment of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea; and Institute of Behavioral Sciences in Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaBackground North Korean defectors (NKDs) have often been exposed to traumatic events. However, there have been few studies of neural alterations in NKDs with post-traumatic stress disorder (PTSD) and complex PTSD (cPTSD). Aims To investigate neural alterations in NKDs with PTSD and cPTSD, with a specific focus on alterations in resting-state functional connectivity networks, including the default mode network (DMN). Method Resting-state functional connectivity was assessed using brain functional magnetic resonance imaging in three groups of NKDs: without PTSD, with PTSD and with cPTSD. Statistical tests were performed, including region of interest (ROI)-to-ROI and ROI-to-voxel analysis, followed by post hoc correlation analysis. Results In the ROI-to-ROI analysis, differences in functional connectivity were found among the components of the DMN, as well as in the thalamus and the basal ganglia. Right hippocampus–left pallidum and right amygdala–left lingual gyrus connectivity differed between groups in the ROI-to-voxel analysis, as did connectivity involving the basal ganglia. The post hoc analysis revealed negative correlations between Coping and Adaptation Processing Scale (CAPS) score and left posterior cingulate cortex–right pallidum connectivity and between CAPS score and right putamen–left angular gyrus connectivity in the control group, which were not observed in other groups. Conclusions The results suggest that there are alterations in the functional connectivity of the DMN and the limbic system in NKDs with PTSD and cPTSD, and that these alterations involve the basal ganglia. The lower correlations of CAPS score with right basal ganglia–DMN functional connectivity in patients compared with controls further implies that these connectivities are potential targets for treatment of PTSD and cPTSD. https://www.cambridge.org/core/product/identifier/S2056472423006361/type/journal_articleNorth Korean defectorsPTSDcomplex PTSDfunctional connectivitydefault mode network |
| spellingShingle | Byung-Hoon Kim Jiwon Baek Ocksim Kim Hokon Kim Minjeong Ko Sang Hui Chu Young-Chul Jung North Korean defectors with PTSD and complex PTSD show alterations in default mode network resting-state functional connectivity BJPsych Open North Korean defectors PTSD complex PTSD functional connectivity default mode network |
| title | North Korean defectors with PTSD and complex PTSD show alterations in default mode network resting-state functional connectivity |
| title_full | North Korean defectors with PTSD and complex PTSD show alterations in default mode network resting-state functional connectivity |
| title_fullStr | North Korean defectors with PTSD and complex PTSD show alterations in default mode network resting-state functional connectivity |
| title_full_unstemmed | North Korean defectors with PTSD and complex PTSD show alterations in default mode network resting-state functional connectivity |
| title_short | North Korean defectors with PTSD and complex PTSD show alterations in default mode network resting-state functional connectivity |
| title_sort | north korean defectors with ptsd and complex ptsd show alterations in default mode network resting state functional connectivity |
| topic | North Korean defectors PTSD complex PTSD functional connectivity default mode network |
| url | https://www.cambridge.org/core/product/identifier/S2056472423006361/type/journal_article |
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