Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review
Antonio Russo, Carmine Minichini, Mario Starace, Roberta Astorri, Federica Calò, Nicola Coppola On behalf of the Vanvitelli COVID-19 groupDepartment of Mental Health and Public Medicine, Infectious Diseases Unit, University of Campania Luigi Vanvitelli, Naples, ItalyCorrespondence: Nicola...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-08-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/current-status-of-laboratory-diagnosis-for-covid-19-a-narrative-review-peer-reviewed-article-IDR |
| _version_ | 1828851735817355264 |
|---|---|
| author | Russo A Minichini C Starace M Astorri R Calò F Coppola N |
| author_facet | Russo A Minichini C Starace M Astorri R Calò F Coppola N |
| author_sort | Russo A |
| collection | DOAJ |
| description | Antonio Russo, Carmine Minichini, Mario Starace, Roberta Astorri, Federica Calò, Nicola Coppola On behalf of the Vanvitelli COVID-19 groupDepartment of Mental Health and Public Medicine, Infectious Diseases Unit, University of Campania Luigi Vanvitelli, Naples, ItalyCorrespondence: Nicola CoppolaDepartment of Mental Health and Public Medicine, Infectious Diseases Unit, University of Campania Luigi Vanvitelli, Via: L. Armanni 5, Naples 80131, ItalyTel +39 0815666719Fax +39 0815666013Email nicola.coppola@unicampania.itAbstract: The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the related disease (COVID-19) has spread rapidly to pandemic proportions, increasing the demands on healthcare systems for the containment and management of COVID-19. One of the critical issues to be addressed is the improvement in laboratory diagnosis and screening of large portions of the population to stop the virus spreading. Currently, the laboratory diagnosis of SARS-CoV-2 infection and the related disease is based on the research of viral RNA with rt-PCR methods in upper and lower respiratory airways. Serological tests to detect SARS-CoV-2 antibodies could help physicians and healthcare workers to support COVID-19 diagnosis and follow-up and perform population screening. Our review, using MEDLINE and EMBASE, summarizes the current knowledge of direct and serological tests performed to research RNA, antigens, or antibodies for SARS-CoV-2, evaluating the advantages and drawbacks for specific tests.Keywords: COVID-19, SARS-CoV-2, laboratory diagnosis, serological test, PCR |
| first_indexed | 2024-12-12T23:37:39Z |
| format | Article |
| id | doaj.art-b6c18984a2274ee6906180ed291a56a6 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-12T23:37:39Z |
| publishDate | 2020-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-b6c18984a2274ee6906180ed291a56a62022-12-22T00:07:21ZengDove Medical PressInfection and Drug Resistance1178-69732020-08-01Volume 132657266555880Current Status of Laboratory Diagnosis for COVID-19: A Narrative ReviewRusso AMinichini CStarace MAstorri RCalò FCoppola NAntonio Russo, Carmine Minichini, Mario Starace, Roberta Astorri, Federica Calò, Nicola Coppola On behalf of the Vanvitelli COVID-19 groupDepartment of Mental Health and Public Medicine, Infectious Diseases Unit, University of Campania Luigi Vanvitelli, Naples, ItalyCorrespondence: Nicola CoppolaDepartment of Mental Health and Public Medicine, Infectious Diseases Unit, University of Campania Luigi Vanvitelli, Via: L. Armanni 5, Naples 80131, ItalyTel +39 0815666719Fax +39 0815666013Email nicola.coppola@unicampania.itAbstract: The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the related disease (COVID-19) has spread rapidly to pandemic proportions, increasing the demands on healthcare systems for the containment and management of COVID-19. One of the critical issues to be addressed is the improvement in laboratory diagnosis and screening of large portions of the population to stop the virus spreading. Currently, the laboratory diagnosis of SARS-CoV-2 infection and the related disease is based on the research of viral RNA with rt-PCR methods in upper and lower respiratory airways. Serological tests to detect SARS-CoV-2 antibodies could help physicians and healthcare workers to support COVID-19 diagnosis and follow-up and perform population screening. Our review, using MEDLINE and EMBASE, summarizes the current knowledge of direct and serological tests performed to research RNA, antigens, or antibodies for SARS-CoV-2, evaluating the advantages and drawbacks for specific tests.Keywords: COVID-19, SARS-CoV-2, laboratory diagnosis, serological test, PCRhttps://www.dovepress.com/current-status-of-laboratory-diagnosis-for-covid-19-a-narrative-review-peer-reviewed-article-IDRcovid-19sars-cov-2laboratory diagnosisserological testpcr |
| spellingShingle | Russo A Minichini C Starace M Astorri R Calò F Coppola N Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review Infection and Drug Resistance covid-19 sars-cov-2 laboratory diagnosis serological test pcr |
| title | Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review |
| title_full | Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review |
| title_fullStr | Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review |
| title_full_unstemmed | Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review |
| title_short | Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review |
| title_sort | current status of laboratory diagnosis for covid 19 a narrative review |
| topic | covid-19 sars-cov-2 laboratory diagnosis serological test pcr |
| url | https://www.dovepress.com/current-status-of-laboratory-diagnosis-for-covid-19-a-narrative-review-peer-reviewed-article-IDR |
| work_keys_str_mv | AT russoa currentstatusoflaboratorydiagnosisforcovid19anarrativereview AT minichinic currentstatusoflaboratorydiagnosisforcovid19anarrativereview AT staracem currentstatusoflaboratorydiagnosisforcovid19anarrativereview AT astorrir currentstatusoflaboratorydiagnosisforcovid19anarrativereview AT calof currentstatusoflaboratorydiagnosisforcovid19anarrativereview AT coppolan currentstatusoflaboratorydiagnosisforcovid19anarrativereview |