Impact of chronic kidney disease stage on morbidity after gastrectomy for gastric cancer
Abstract Aim The outcomes of gastrectomy for gastric cancer in patients at each severity of chronic kidney disease (CKD) remain unknown. Methods We retrospectively analyzed the outcomes of 560 patients who underwent distal or total gastrectomy for gastric cancer between 2009 and 2018. We classified...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | Annals of Gastroenterological Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ags3.12441 |
| _version_ | 1827989789741154304 |
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| author | Satoshi Suzuki Shingo Kanaji Naoki Urakawa Gosuke Takiguchi Hiroshi Hasegawa Kimihiro Yamashita Takeru Matsuda Taro Oshikiri Tetsu Nakamura Yoshihiro Kakeji |
| author_facet | Satoshi Suzuki Shingo Kanaji Naoki Urakawa Gosuke Takiguchi Hiroshi Hasegawa Kimihiro Yamashita Takeru Matsuda Taro Oshikiri Tetsu Nakamura Yoshihiro Kakeji |
| author_sort | Satoshi Suzuki |
| collection | DOAJ |
| description | Abstract Aim The outcomes of gastrectomy for gastric cancer in patients at each severity of chronic kidney disease (CKD) remain unknown. Methods We retrospectively analyzed the outcomes of 560 patients who underwent distal or total gastrectomy for gastric cancer between 2009 and 2018. We classified the patients into four groups based on estimated glomerular filtration rate: stage 1/2 (normal to mild, n = 375), stage 3a (mild to moderate, n = 122), stage 3b (moderate to severe, n = 43), and stage 4/5 (severe to end‐stage, n = 20) CKD. The relationship between CKD stage and the incidence of postoperative morbidity was analyzed. Results CKD was a predictor of overall morbidity independent of age, gender, American Society of Anesthesiologists Performance Status, pulmonary comorbidity, extent of lymphadenectomy, and operation time in a multivariate analysis. The incidences of overall and severe morbidity were significantly increased with CKD progression (both P < .001). Compared to stage 1/2 CKD, the odds of overall morbidity were significantly elevated in stage 3a (odds ratio [OR] 1.87, P = .007), stage 3b (OR 3.86, P < .001), and stage 4/5 (OR 8.60, P < .001). The risk of procedure‐related morbidity was strikingly increased in stage 3b (OR 2.93, P = .004). The risk of procedure‐unrelated morbidity elevated markedly in stage 3a (OR 2.77, P = .001). A significant graded association between CKD progression and overall morbidity was also revealed in elderly patients (P = .001). Conclusions The severity of CKD predicts the likelihood and type of morbidity after gastrectomy and can guide surgical decision‐making for patients with gastric cancer. |
| first_indexed | 2024-04-10T00:25:49Z |
| format | Article |
| id | doaj.art-b6c1e83100ad40099a9e659a6907bc8f |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-04-10T00:25:49Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-b6c1e83100ad40099a9e659a6907bc8f2023-03-15T10:05:47ZengWileyAnnals of Gastroenterological Surgery2475-03282021-07-015451952710.1002/ags3.12441Impact of chronic kidney disease stage on morbidity after gastrectomy for gastric cancerSatoshi Suzuki0Shingo Kanaji1Naoki Urakawa2Gosuke Takiguchi3Hiroshi Hasegawa4Kimihiro Yamashita5Takeru Matsuda6Taro Oshikiri7Tetsu Nakamura8Yoshihiro Kakeji9Division of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanDivision of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanDivision of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanDivision of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanDivision of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanDivision of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanDivision of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanDivision of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanDivision of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanDivision of Gatrointestinal Surgery Department of Surgery Graduate School of medicine Kobe University Kobe JapanAbstract Aim The outcomes of gastrectomy for gastric cancer in patients at each severity of chronic kidney disease (CKD) remain unknown. Methods We retrospectively analyzed the outcomes of 560 patients who underwent distal or total gastrectomy for gastric cancer between 2009 and 2018. We classified the patients into four groups based on estimated glomerular filtration rate: stage 1/2 (normal to mild, n = 375), stage 3a (mild to moderate, n = 122), stage 3b (moderate to severe, n = 43), and stage 4/5 (severe to end‐stage, n = 20) CKD. The relationship between CKD stage and the incidence of postoperative morbidity was analyzed. Results CKD was a predictor of overall morbidity independent of age, gender, American Society of Anesthesiologists Performance Status, pulmonary comorbidity, extent of lymphadenectomy, and operation time in a multivariate analysis. The incidences of overall and severe morbidity were significantly increased with CKD progression (both P < .001). Compared to stage 1/2 CKD, the odds of overall morbidity were significantly elevated in stage 3a (odds ratio [OR] 1.87, P = .007), stage 3b (OR 3.86, P < .001), and stage 4/5 (OR 8.60, P < .001). The risk of procedure‐related morbidity was strikingly increased in stage 3b (OR 2.93, P = .004). The risk of procedure‐unrelated morbidity elevated markedly in stage 3a (OR 2.77, P = .001). A significant graded association between CKD progression and overall morbidity was also revealed in elderly patients (P = .001). Conclusions The severity of CKD predicts the likelihood and type of morbidity after gastrectomy and can guide surgical decision‐making for patients with gastric cancer.https://doi.org/10.1002/ags3.12441chronic renal diseasegastrectomygastric cancerglomerular filtration rate |
| spellingShingle | Satoshi Suzuki Shingo Kanaji Naoki Urakawa Gosuke Takiguchi Hiroshi Hasegawa Kimihiro Yamashita Takeru Matsuda Taro Oshikiri Tetsu Nakamura Yoshihiro Kakeji Impact of chronic kidney disease stage on morbidity after gastrectomy for gastric cancer Annals of Gastroenterological Surgery chronic renal disease gastrectomy gastric cancer glomerular filtration rate |
| title | Impact of chronic kidney disease stage on morbidity after gastrectomy for gastric cancer |
| title_full | Impact of chronic kidney disease stage on morbidity after gastrectomy for gastric cancer |
| title_fullStr | Impact of chronic kidney disease stage on morbidity after gastrectomy for gastric cancer |
| title_full_unstemmed | Impact of chronic kidney disease stage on morbidity after gastrectomy for gastric cancer |
| title_short | Impact of chronic kidney disease stage on morbidity after gastrectomy for gastric cancer |
| title_sort | impact of chronic kidney disease stage on morbidity after gastrectomy for gastric cancer |
| topic | chronic renal disease gastrectomy gastric cancer glomerular filtration rate |
| url | https://doi.org/10.1002/ags3.12441 |
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