Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis
Ischemic stroke is a common issue that severely affects the human health. Between the central nervous system and the enteric system, the '' Gut-Brain '' axis, the bidirectional connection involved in the neuro-immuno-endocrine network, is crucial for the occurrence and developmen...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222014457 |
| _version_ | 1811299689469837312 |
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| author | Zhe Zhai Pei-Wei Su Lan-ying Ma Hui Yang Tong Wang Zheng-Gen Fei Ya-Nan Zhang Yuan Wang Ke Ma Bing-Bing Han Zhi-Chun Wu Hua-Yun Yu Hai-Jun Zhao |
| author_facet | Zhe Zhai Pei-Wei Su Lan-ying Ma Hui Yang Tong Wang Zheng-Gen Fei Ya-Nan Zhang Yuan Wang Ke Ma Bing-Bing Han Zhi-Chun Wu Hua-Yun Yu Hai-Jun Zhao |
| author_sort | Zhe Zhai |
| collection | DOAJ |
| description | Ischemic stroke is a common issue that severely affects the human health. Between the central nervous system and the enteric system, the '' Gut-Brain '' axis, the bidirectional connection involved in the neuro-immuno-endocrine network, is crucial for the occurrence and development of ischemic stroke. Ischemic stroke can lead to change in the gut microbiota and gastrointestinal hormones, which will then reversely affect the disease development. Traditional Chinese Medicine (TCM) has unique advantages with reference to the treatment for ischemic stroke. The latest research revealed that a significant portion of medicines and prescriptions of TCM exert their therapeutic effects by improving the gut microbiota and regulating the secretion of gastrointestinal hormones. The present review summarized the Chinese medicines that play a therapeutic role in cerebral ischemia through regulating the ''Gut-Brain'' axis and described the corresponding mechanisms. This study attempts to provide reference for clinical selection of Chinese medicines and helps better understand the relevant mechanisms of action. |
| first_indexed | 2024-04-13T06:40:32Z |
| format | Article |
| id | doaj.art-b6c30b8d183b44ee974eb82ce5874ba7 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T06:40:32Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-b6c30b8d183b44ee974eb82ce5874ba72022-12-22T02:57:46ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-01-01157114056Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axisZhe Zhai0Pei-Wei Su1Lan-ying Ma2Hui Yang3Tong Wang4Zheng-Gen Fei5Ya-Nan Zhang6Yuan Wang7Ke Ma8Bing-Bing Han9Zhi-Chun Wu10Hua-Yun Yu11Hai-Jun Zhao12College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Jinan, China; Corresponding author at: College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.Ischemic stroke is a common issue that severely affects the human health. Between the central nervous system and the enteric system, the '' Gut-Brain '' axis, the bidirectional connection involved in the neuro-immuno-endocrine network, is crucial for the occurrence and development of ischemic stroke. Ischemic stroke can lead to change in the gut microbiota and gastrointestinal hormones, which will then reversely affect the disease development. Traditional Chinese Medicine (TCM) has unique advantages with reference to the treatment for ischemic stroke. The latest research revealed that a significant portion of medicines and prescriptions of TCM exert their therapeutic effects by improving the gut microbiota and regulating the secretion of gastrointestinal hormones. The present review summarized the Chinese medicines that play a therapeutic role in cerebral ischemia through regulating the ''Gut-Brain'' axis and described the corresponding mechanisms. This study attempts to provide reference for clinical selection of Chinese medicines and helps better understand the relevant mechanisms of action.http://www.sciencedirect.com/science/article/pii/S0753332222014457Ischemic stroke''Gut-Brain'' axisVagus nerveGut microbiotaGastrointestinal hormoneTraditional Chinese medicine |
| spellingShingle | Zhe Zhai Pei-Wei Su Lan-ying Ma Hui Yang Tong Wang Zheng-Gen Fei Ya-Nan Zhang Yuan Wang Ke Ma Bing-Bing Han Zhi-Chun Wu Hua-Yun Yu Hai-Jun Zhao Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis Biomedicine & Pharmacotherapy Ischemic stroke ''Gut-Brain'' axis Vagus nerve Gut microbiota Gastrointestinal hormone Traditional Chinese medicine |
| title | Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis |
| title_full | Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis |
| title_fullStr | Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis |
| title_full_unstemmed | Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis |
| title_short | Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis |
| title_sort | progress on traditional chinese medicine in treatment of ischemic stroke via the gut brain axis |
| topic | Ischemic stroke ''Gut-Brain'' axis Vagus nerve Gut microbiota Gastrointestinal hormone Traditional Chinese medicine |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222014457 |
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