A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts

A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts

SWATH-mass spectrometry (MS) enables accurate and reproducible proteomic profiling in multiple model organisms including the mouse. Here, we present a comprehensive mouse reference spectral library (MouseRefSWATH) that permits quantification of up to 10,597 proteins (62.2% of the mouse proteome) by...

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Bibliographic Details
Main Authors: Lukas Krasny, Philip Bland, Jessica Burns, Nadia Carvalho Lima, Peter T. Harrison, Laura Pacini, Mark L. Elms, Jian Ning, Victor Garcia Martinez, Yi-Ru Yu, Sophie E. Acton, Ping-Chih Ho, Fernando Calvo, Amanda Swain, Beatrice A. Howard, Rachael C. Natrajan, Paul H. Huang
Format: Article
Language:English
Published: The Company of Biologists 2020-07-01
Series:Disease Models & Mechanisms
Subjects:
mass spectrometry
swath-ms
proteomics
mouse
xenografts
dcis
breast cancer
Online Access:http://dmm.biologists.org/content/13/7/dmm044586

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