Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review
Hepatitis C Virus (HCV) infection represents a huge burden on healthcare systems worldwide. Vachellia nilotica (V. nilotica) is a widely used plant specie in folk medicine for viral diseases and in some communities for HCV infection. However, little is known regarding its role and possible mechanism...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Scientific African |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468227621002222 |
| _version_ | 1819121633770602496 |
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| author | Lucrèce Y.J. Ahovègbé Patrick E. Ogwang Emanuel L. Peter Andrew G. Mtewa Félicien M. Kasali Casim U. Tolo Judith Gbenoudon Anke Weisheit Kamba F. Pakoyo |
| author_facet | Lucrèce Y.J. Ahovègbé Patrick E. Ogwang Emanuel L. Peter Andrew G. Mtewa Félicien M. Kasali Casim U. Tolo Judith Gbenoudon Anke Weisheit Kamba F. Pakoyo |
| author_sort | Lucrèce Y.J. Ahovègbé |
| collection | DOAJ |
| description | Hepatitis C Virus (HCV) infection represents a huge burden on healthcare systems worldwide. Vachellia nilotica (V. nilotica) is a widely used plant specie in folk medicine for viral diseases and in some communities for HCV infection. However, little is known regarding its role and possible mechanisms in the prevention and treatment of this viral infection. This review presents ethno-pharmacological, in vitro and in vivo shreds of evidence of the role and underlying mode of action of V. nilotica and its implication in treatment and complication management of HCV infection. PubMed, Library of Congress, SCOPUS, Science Direct and Google scholar databases were searched. Twenty-eight articles of which 15 were in vitro while remaining were in vivo studies were reviewed. V. nilotica's modes of antiviral activity are direct inactivation of HCV and inhibition of HCV NS3 protease. Its immuno-modulatory activity showed by immune cell proliferation and inhibition of immunosuppressive cytokine. V. nilotica's anticancer activity through inhibition of oxidative stress, inhibition of chromosomal aberrations and enhancement of antioxidant enzymes could be beneficial in treating HCV infection and delaying its progression to cancer. It can be inferred that V. nilotica could be a promising source of anti-hepatitis C virus drug leads with the ability to prevent its long-term sequelae while promoting immune competence. Further studies are needed to explore the applicability of the herb to clinical settings. |
| first_indexed | 2024-12-22T06:39:40Z |
| format | Article |
| id | doaj.art-b6c576a3fe5d46158b7879146aba90b6 |
| institution | Directory Open Access Journal |
| issn | 2468-2276 |
| language | English |
| last_indexed | 2024-12-22T06:39:40Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Scientific African |
| spelling | doaj.art-b6c576a3fe5d46158b7879146aba90b62022-12-21T18:35:28ZengElsevierScientific African2468-22762021-09-0113e00918Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A reviewLucrèce Y.J. Ahovègbé0Patrick E. Ogwang1Emanuel L. Peter2Andrew G. Mtewa3Félicien M. Kasali4Casim U. Tolo5Judith Gbenoudon6Anke Weisheit7Kamba F. Pakoyo8Pharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, P. O. Box 1410, Mbarara, Uganda; Laboratory of Immunology, Infectious and Allergic Diseases, ISBA and FAST, University of Abomey-Calavi, P.O. BOX: 04 BP 1221 Cotonou, Benin; Corresponding author at: Mbarara University of Science and Technology Faculty of Medicine, Mbarara, Mbarara, Uganda.Pharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, P. O. Box 1410, Mbarara, UgandaPharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, P. O. Box 1410, Mbarara, Uganda; Department of Innovation, Technology Transfer & Commercialization, National Institute for Medical Research, 2448 Baracka Obama drive, P.O. Box 9653, Dar Es Salaam, TanzaniaPharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, P. O. Box 1410, Mbarara, Uganda; Chemistry Section, Department of Applied Science, MIT, Malawi University of Science and Technology, Thyolo, MalawiPharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, P. O. Box 1410, Mbarara, Uganda; Department of Pharmacy, Faculty of Pharmaceutical Sciences and Public Health, Official University of Bukavu, Democratic Republic of CongoPharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, P. O. Box 1410, Mbarara, UgandaLaboratory of Immunology, Infectious and Allergic Diseases, ISBA and FAST, University of Abomey-Calavi, P.O. BOX: 04 BP 1221 Cotonou, BeninPharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, P. O. Box 1410, Mbarara, UgandaDepartment of Pharmacy, School of Health Sciences, Makerere University, Kampala, UgandaHepatitis C Virus (HCV) infection represents a huge burden on healthcare systems worldwide. Vachellia nilotica (V. nilotica) is a widely used plant specie in folk medicine for viral diseases and in some communities for HCV infection. However, little is known regarding its role and possible mechanisms in the prevention and treatment of this viral infection. This review presents ethno-pharmacological, in vitro and in vivo shreds of evidence of the role and underlying mode of action of V. nilotica and its implication in treatment and complication management of HCV infection. PubMed, Library of Congress, SCOPUS, Science Direct and Google scholar databases were searched. Twenty-eight articles of which 15 were in vitro while remaining were in vivo studies were reviewed. V. nilotica's modes of antiviral activity are direct inactivation of HCV and inhibition of HCV NS3 protease. Its immuno-modulatory activity showed by immune cell proliferation and inhibition of immunosuppressive cytokine. V. nilotica's anticancer activity through inhibition of oxidative stress, inhibition of chromosomal aberrations and enhancement of antioxidant enzymes could be beneficial in treating HCV infection and delaying its progression to cancer. It can be inferred that V. nilotica could be a promising source of anti-hepatitis C virus drug leads with the ability to prevent its long-term sequelae while promoting immune competence. Further studies are needed to explore the applicability of the herb to clinical settings.http://www.sciencedirect.com/science/article/pii/S2468227621002222Vachellia niloticaHepatitis CAntiviral;AntioxidantAnti-mutagenicImmuno-modulatory |
| spellingShingle | Lucrèce Y.J. Ahovègbé Patrick E. Ogwang Emanuel L. Peter Andrew G. Mtewa Félicien M. Kasali Casim U. Tolo Judith Gbenoudon Anke Weisheit Kamba F. Pakoyo Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review Scientific African Vachellia nilotica Hepatitis C Antiviral; Antioxidant Anti-mutagenic Immuno-modulatory |
| title | Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review |
| title_full | Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review |
| title_fullStr | Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review |
| title_full_unstemmed | Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review |
| title_short | Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review |
| title_sort | therapeutic potentials of vachellia nilotica l extracts in hepatitis c infection a review |
| topic | Vachellia nilotica Hepatitis C Antiviral; Antioxidant Anti-mutagenic Immuno-modulatory |
| url | http://www.sciencedirect.com/science/article/pii/S2468227621002222 |
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