Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase

On an organismal level, metabolism needs to react in a well-orchestrated manner to metabolic challenges such as nutrient uptake. Key metabolic hubs in human blood are pyruvate and lactate, both of which are constantly interconverted by very fast exchange fluxes. The quantitative contribution of diff...

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Bibliographic Details
Main Authors: Lisa Schlicker, Gang Zhao, Christian-Alexander Dudek, Hanny M. Boers, Michael Meyer-Hermann, Doris M. Jacobs, Karsten Hiller
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Nutrition
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.785999/full