Alterations in Interhemispheric Functional and Anatomical Connectivity are Associated with Tobacco Smoking in Humans
Abnormal interhemispheric functional connectivity correlates with several neurologic and psychiatric conditions, including depression, obsessive-compulsive disorder, schizophrenia, and stroke. Abnormal interhemispheric functional connectivity also correlates with abuse of cannabis and cocaine. In th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-03-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00116/full |
| _version_ | 1819157503609405440 |
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| author | Humsini eViswanath Kenia M Velasquez Daisy Gemma Yan Thompson Lake Ricky eSavjani Asasia Q Carter David M Eagleman Philip R Baldwin Richard eDe La Garza Ramiro eSalas |
| author_facet | Humsini eViswanath Kenia M Velasquez Daisy Gemma Yan Thompson Lake Ricky eSavjani Asasia Q Carter David M Eagleman Philip R Baldwin Richard eDe La Garza Ramiro eSalas |
| author_sort | Humsini eViswanath |
| collection | DOAJ |
| description | Abnormal interhemispheric functional connectivity correlates with several neurologic and psychiatric conditions, including depression, obsessive-compulsive disorder, schizophrenia, and stroke. Abnormal interhemispheric functional connectivity also correlates with abuse of cannabis and cocaine. In the current report, we evaluated whether tobacco abuse (i.e., cigarette smoking) is associated with altered interhemispheric connectivity. To that end, we examined resting state functional connectivity using magnetic resonance imaging (MRI) in short term tobacco deprived and smoking as usual tobacco smokers, and in non-smoker controls. Additionally, we compared diffusion tensor imaging (DTI) in the same subjects to study differences in white matter. The data reveal a significant increase in interhemispheric functional connectivity in sated tobacco smokers when compared to controls. This difference was larger in frontal regions, and was positively correlated with the average number of cigarettes smoked per day. In addition, we found a negative correlation between the number of DTI streamlines in the genual corpus callosum and the number of cigarettes smoked per day. Taken together, our results implicate changes in interhemispheric functional and anatomical connectivity in current cigarette smokers. |
| first_indexed | 2024-12-22T16:09:48Z |
| format | Article |
| id | doaj.art-b6c717e722f046498f7905c66375e9f5 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T16:09:48Z |
| publishDate | 2015-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-b6c717e722f046498f7905c66375e9f52022-12-21T18:20:31ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-03-01910.3389/fnhum.2015.00116127217Alterations in Interhemispheric Functional and Anatomical Connectivity are Associated with Tobacco Smoking in HumansHumsini eViswanath0Kenia M Velasquez1Daisy Gemma Yan Thompson Lake2Ricky eSavjani3Asasia Q Carter4David M Eagleman5Philip R Baldwin6Richard eDe La Garza7Ramiro eSalas8Baylor College of MedicineBaylor College of MedicineBaylor College of MedicineBaylor College of MedicineBaylor College of MedicineBaylor College of MedicineBaylor College of MedicineBaylor College of MedicineBaylor College of MedicineAbnormal interhemispheric functional connectivity correlates with several neurologic and psychiatric conditions, including depression, obsessive-compulsive disorder, schizophrenia, and stroke. Abnormal interhemispheric functional connectivity also correlates with abuse of cannabis and cocaine. In the current report, we evaluated whether tobacco abuse (i.e., cigarette smoking) is associated with altered interhemispheric connectivity. To that end, we examined resting state functional connectivity using magnetic resonance imaging (MRI) in short term tobacco deprived and smoking as usual tobacco smokers, and in non-smoker controls. Additionally, we compared diffusion tensor imaging (DTI) in the same subjects to study differences in white matter. The data reveal a significant increase in interhemispheric functional connectivity in sated tobacco smokers when compared to controls. This difference was larger in frontal regions, and was positively correlated with the average number of cigarettes smoked per day. In addition, we found a negative correlation between the number of DTI streamlines in the genual corpus callosum and the number of cigarettes smoked per day. Taken together, our results implicate changes in interhemispheric functional and anatomical connectivity in current cigarette smokers.http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00116/fullCorpus CallosumDiffusion Tensor Imaginginterhemispheric connectivityresting state functional connectivitytobacco smoking |
| spellingShingle | Humsini eViswanath Kenia M Velasquez Daisy Gemma Yan Thompson Lake Ricky eSavjani Asasia Q Carter David M Eagleman Philip R Baldwin Richard eDe La Garza Ramiro eSalas Alterations in Interhemispheric Functional and Anatomical Connectivity are Associated with Tobacco Smoking in Humans Frontiers in Human Neuroscience Corpus Callosum Diffusion Tensor Imaging interhemispheric connectivity resting state functional connectivity tobacco smoking |
| title | Alterations in Interhemispheric Functional and Anatomical Connectivity are Associated with Tobacco Smoking in Humans |
| title_full | Alterations in Interhemispheric Functional and Anatomical Connectivity are Associated with Tobacco Smoking in Humans |
| title_fullStr | Alterations in Interhemispheric Functional and Anatomical Connectivity are Associated with Tobacco Smoking in Humans |
| title_full_unstemmed | Alterations in Interhemispheric Functional and Anatomical Connectivity are Associated with Tobacco Smoking in Humans |
| title_short | Alterations in Interhemispheric Functional and Anatomical Connectivity are Associated with Tobacco Smoking in Humans |
| title_sort | alterations in interhemispheric functional and anatomical connectivity are associated with tobacco smoking in humans |
| topic | Corpus Callosum Diffusion Tensor Imaging interhemispheric connectivity resting state functional connectivity tobacco smoking |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00116/full |
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