Intensity Modulated Radiotherapy (IMRT) Versus Helical Tomotherapy (HT) in Esophageal Cancer: A Comparative Analysis
Purpose/Objectives: Definitive chemoradiation is an accepted alternative treatment in the management of esophageal cancer in patients who are not candidates for surgery. The location of esophagus poses a challenge because of its close proximity to the critical organs. Various modern techniques of ra...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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West Asia Organization for Cancer Prevention
2023-05-01
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| Series: | Asian Pacific Journal of Cancer Care |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcc/article/view/1076 |
| _version_ | 1797342261633089536 |
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| author | Manasa Penumur Smriti Goswami Bibhash Chandra Goswami Diplu Choudhury Fahim Arman Hassan Ghritashee Bora Luri Borah Moumita Paul Rheetwik Baruah Dimpal Saikia Kalyanjit Dutta Baruah |
| author_facet | Manasa Penumur Smriti Goswami Bibhash Chandra Goswami Diplu Choudhury Fahim Arman Hassan Ghritashee Bora Luri Borah Moumita Paul Rheetwik Baruah Dimpal Saikia Kalyanjit Dutta Baruah |
| author_sort | Manasa Penumur |
| collection | DOAJ |
| description | Purpose/Objectives: Definitive chemoradiation is an accepted alternative treatment in the management of esophageal cancer in patients who are not candidates for surgery. The location of esophagus poses a challenge because of its close proximity to the critical organs. Various modern techniques of radiation planning offer the advantage of better dose conformality and increased sparing of organs at risk. This study aims to compare the dosimetric parameters of Intensity Modulated Radiotherapy (IMRT) and Helical Tomotherapy (HT) planning techniques in radical radiotherapy for esophageal cancer patients.
Materials/Methods: A total of 38 patients of esophageal squamous cell carcinoma with clinical staging cT2-T4/N0-N2/M0 planned for definitive chemoradiation were enrolled from June 2021 till November 2022. CT simulation was done with intravenous and oral contrast, and contouring of tumor volumes and organs at risk were done according to RTOG contouring guidelines. All patients were planned for a total dose of 50.4Gy in 28 fractions. Radiation plans of IMRT and HT were generated for each patient. Dosimetric parameters of PTV D98, D2, Dmean, V95, V110, Homogeneity Index (HI) and Conformity Index (CI) were noted for both the plans. Organs at risk (OAR) parameters such as Lung (V20, V30, V5, Dmean), Heart (V25, V30, Dmean), Spinal Cord Dmax, Larynx (Dmax, Dmean) and Liver Dmean were noted. All parameters of the two different planning techniques were compared and analyzed using SPSS software v23 with paired t-test.
Results: The coverage of the PTV in IMRT and HT was similar in terms of PTV V95 and PTV D98. The regions receiving more than 107% and 110% of the prescribed dose was significantly higher in IMRT compared to HT, on assessing V107, V110 and D2 (p=0.001). HI was similar in both the groups, but the CI was significantly better in HT compared to IMRT (0.9 ± 0.02 vs 1.03 ± 0.01; p=0.002). Doses to the lungs, heart and liver were similar between the two groups. IMRT had higher spinal cord (39.1 ± 3.2 vs 34.2 ± 5.5; p=0.001) and laryngeal dose (9.6 ± 5.5 vs 5.6 ± 3.7; p=0.009) compared to HT.
Conclusion: HT offers better dose conformality and uniformity when compared to IMRT with lesser dose to spinal cord and larynx. As this is a dosimetric study, a larger sample size and patient follow up is essential for clinical correlation and assessment of benefit of different radiation modalities. |
| first_indexed | 2024-03-08T10:30:45Z |
| format | Article |
| id | doaj.art-b6c73453c8f14549ac6cfbe9026a5cf9 |
| institution | Directory Open Access Journal |
| issn | 2588-3682 |
| language | English |
| last_indexed | 2024-03-08T10:30:45Z |
| publishDate | 2023-05-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Care |
| spelling | doaj.art-b6c73453c8f14549ac6cfbe9026a5cf92024-01-27T06:45:21ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Care2588-36822023-05-018230130610.31557/apjcc.2023.8.2.301-3061076Intensity Modulated Radiotherapy (IMRT) Versus Helical Tomotherapy (HT) in Esophageal Cancer: A Comparative AnalysisManasa Penumur0Smriti Goswami1Bibhash Chandra Goswami2Diplu Choudhury3Fahim Arman Hassan4Ghritashee Bora5Luri Borah6Moumita Paul7Rheetwik Baruah8Dimpal Saikia9Kalyanjit Dutta Baruah10Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Department of Radiation Oncology, State Cancer Institute, Gauhati Medical College, Guwahati, Assam, India.Purpose/Objectives: Definitive chemoradiation is an accepted alternative treatment in the management of esophageal cancer in patients who are not candidates for surgery. The location of esophagus poses a challenge because of its close proximity to the critical organs. Various modern techniques of radiation planning offer the advantage of better dose conformality and increased sparing of organs at risk. This study aims to compare the dosimetric parameters of Intensity Modulated Radiotherapy (IMRT) and Helical Tomotherapy (HT) planning techniques in radical radiotherapy for esophageal cancer patients. Materials/Methods: A total of 38 patients of esophageal squamous cell carcinoma with clinical staging cT2-T4/N0-N2/M0 planned for definitive chemoradiation were enrolled from June 2021 till November 2022. CT simulation was done with intravenous and oral contrast, and contouring of tumor volumes and organs at risk were done according to RTOG contouring guidelines. All patients were planned for a total dose of 50.4Gy in 28 fractions. Radiation plans of IMRT and HT were generated for each patient. Dosimetric parameters of PTV D98, D2, Dmean, V95, V110, Homogeneity Index (HI) and Conformity Index (CI) were noted for both the plans. Organs at risk (OAR) parameters such as Lung (V20, V30, V5, Dmean), Heart (V25, V30, Dmean), Spinal Cord Dmax, Larynx (Dmax, Dmean) and Liver Dmean were noted. All parameters of the two different planning techniques were compared and analyzed using SPSS software v23 with paired t-test. Results: The coverage of the PTV in IMRT and HT was similar in terms of PTV V95 and PTV D98. The regions receiving more than 107% and 110% of the prescribed dose was significantly higher in IMRT compared to HT, on assessing V107, V110 and D2 (p=0.001). HI was similar in both the groups, but the CI was significantly better in HT compared to IMRT (0.9 ± 0.02 vs 1.03 ± 0.01; p=0.002). Doses to the lungs, heart and liver were similar between the two groups. IMRT had higher spinal cord (39.1 ± 3.2 vs 34.2 ± 5.5; p=0.001) and laryngeal dose (9.6 ± 5.5 vs 5.6 ± 3.7; p=0.009) compared to HT. Conclusion: HT offers better dose conformality and uniformity when compared to IMRT with lesser dose to spinal cord and larynx. As this is a dosimetric study, a larger sample size and patient follow up is essential for clinical correlation and assessment of benefit of different radiation modalities.http://www.waocp.com/journal/index.php/apjcc/article/view/1076esophageal cancerdosimetryimrttomotherapy |
| spellingShingle | Manasa Penumur Smriti Goswami Bibhash Chandra Goswami Diplu Choudhury Fahim Arman Hassan Ghritashee Bora Luri Borah Moumita Paul Rheetwik Baruah Dimpal Saikia Kalyanjit Dutta Baruah Intensity Modulated Radiotherapy (IMRT) Versus Helical Tomotherapy (HT) in Esophageal Cancer: A Comparative Analysis Asian Pacific Journal of Cancer Care esophageal cancer dosimetry imrt tomotherapy |
| title | Intensity Modulated Radiotherapy (IMRT) Versus Helical Tomotherapy (HT) in Esophageal Cancer: A Comparative Analysis |
| title_full | Intensity Modulated Radiotherapy (IMRT) Versus Helical Tomotherapy (HT) in Esophageal Cancer: A Comparative Analysis |
| title_fullStr | Intensity Modulated Radiotherapy (IMRT) Versus Helical Tomotherapy (HT) in Esophageal Cancer: A Comparative Analysis |
| title_full_unstemmed | Intensity Modulated Radiotherapy (IMRT) Versus Helical Tomotherapy (HT) in Esophageal Cancer: A Comparative Analysis |
| title_short | Intensity Modulated Radiotherapy (IMRT) Versus Helical Tomotherapy (HT) in Esophageal Cancer: A Comparative Analysis |
| title_sort | intensity modulated radiotherapy imrt versus helical tomotherapy ht in esophageal cancer a comparative analysis |
| topic | esophageal cancer dosimetry imrt tomotherapy |
| url | http://www.waocp.com/journal/index.php/apjcc/article/view/1076 |
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